Every edited bi Liu name

Following the release of core technologies such as blade battery, CTB and easy Sifang, BYD (SZ002594, share price of 251 yuan, total market value of 730.7 billion yuan) launched another core technology.

Image source:BYD

According to BYD Auto News, on April 10th, BYD released a new energy-specific intelligent body control system — — Cloud chariot. The intelligent body control system of Yunqi is developed by BYD, which also indicates that BYD has become a China automobile enterprise that can independently master the intelligent body control system.The product matrix of Yunqi includes Yunqi -C, Yunqi -A, Yunqi -P and other products.

According to Wang Chuanfu, chairman and president of BYD, Yunqi is the first exclusive intelligent body control system for new energy in the industry, which not only fills the technical gap in this field in China, but also achieves a breakthrough from 0 to 1, surpassing the technical level of foreign countries and achieving an improvement from 1 to 2.

It is reported that,Yunqi will be carried on the flagship model of BYD Dynasty Ocean, Tengshi, Wangwang and BYD professional personalized brand models.

Image source:BYD

Nowadays, with the technological upgrading of automobile enterprises in China, many China brands have successively launched their own body control systems, and the Yunqi body control system built by BYD this time is specially designed for new energy vehicles. It is reported that "Yun Che" comes from the Book of Wei, and its name was inspired by the ancient imperial car "Che" in China.

Wang Chuanfu said,Yunqi is the first body system to systematically solve the body control problem in the vertical direction. The system can sense the status of people, vehicles and roads in real time, and can keep the vehicle comfortable under complex road conditions.

It is reported that the architecture of the cloud system covers the perception layer, the decision-making layer and the execution layer, and has the characteristics of intelligent perception, accurate decision-making and efficient execution, which can realize the integration of people, vehicles, roads, clouds and systems, ensure the timeliness and accuracy of vehicle signal acquisition, and make the posture of the car body more stable and the drivers in the car more calm.

Image source:BYD

In terms of safety, thanks to the application of cloud technology, the overall safety of vehicles will be further improved.In the most extreme case, even if one wheel is lost, the vehicle can still keep running smoothly. Wang Chuanfu revealed.

At the event site, Lian Yubo, executive vice president of BYD Group and president of Automotive Engineering Research Institute, further introduced the characteristics of Yunqi body control system.

It is reported that Yunqi system is divided into Yunqi -A intelligent air body control system, Yunqi -C intelligent damping body control system, Yunqi -P intelligent hydraulic body control system and other system architectures. According to the characteristics of each version, BYD will gradually apply the cloud technology to the ocean models of Dynasty, Tengshi, Wangwang and professional personalized brands.

Not only that, at the end of the event,BYD also specially released an "egg", announced the Yunqi -X system, and conducted a live demonstration through BYD’s million-class luxury models.

Image source:BYD

Lian Yubo said that the wave of intelligence has brought new technology of vertical direction control, safety is the bottom line and comfort is the high order. The cloud-based system has multiple modules such as cloud-based intelligent detection, cloud-based preview, cloud-based intelligent calculation center and cloud-based intelligent control, which can pass multiple safety certifications and redundant backups in both hardware and software at the same time to ensure the safety of vehicles.

In fact, Yunqi system is not the first core technology independently developed by BYD. Wang Chuanfu revealed that in the 20 years since it entered the new energy vehicle track, BYD has invested 100 billion yuan in research and development, with a team of 69,000 people and 28,000 authorized patents.

In March 2023, BYD sold 207,080 new energy vehicles, compared with 104,878 vehicles in the same period last year. In the first three months, the cumulative sales volume was 552,076 vehicles, a year-on-year increase of 92.81%.

It is worth noting that the sales of BYD’s high-end models Tengshi ushered in a breakthrough. In March, Tengshi’s monthly sales exceeded 10,000, reaching 10,398 vehicles, an increase of 42% from the previous month. Tengshi released the first high-end MPV product, Tengshi D9, in May last year, with a pre-sale price of 335,000-460,000 yuan.

BYD also disclosed that in March 2023, 13,312 new energy passenger cars were sold overseas. In March, the total installed capacity of power batteries and energy storage batteries of new energy vehicles was about 9.891GWh, and the total installed capacity in 2023 was about 26.991GWh.

Recently, many senior executives of BYD, including Chairman and President Wang Chuanfu, attended a performance briefing for investors in Hong Kong. During the period, some investors asked whether BYD could replace Volkswagen’s peak position in the era of oil vehicles in the era of electric vehicles becoming mainstream. BYD responded that in 2022, the new energy vehicle market was in short supply, but in 2023, the situation of insufficient production capacity and material shortage was greatly improved, and the industry would enter the knockout stage. In January and February this year, the total market plate decreased year-on-year, but the new energy increased year-on-year, and the company contributed the main increase, and the market share further increased. From the perspective of subsequent development, the company has pricing power at the price of 100,000-200,000 yuan.

In terms of performance, BYD’s recent 2022 performance shows that the company achieved operating income of 424.061 billion yuan, a year-on-year increase of 96.2%; The net profit attributable to shareholders of listed companies was 16.622 billion yuan, a year-on-year increase of 445.86%; Non-net profit was 15.638 billion yuan, up by 1,146.42% year-on-year, and all core operating data reached record highs.

"Going out to sea" is another highlight of BYD in 2022, and its new energy passenger cars have entered 43 countries and regions such as Japan, Germany, Australia and Brazil.

The person in charge of BYD said that despite the intensified competition in the automobile market this year, the company will continue to maintain a strong growth momentum as Tengshi and Wangwang accelerate the capture of the high-end market, drive BYD’s brand image to continue to rise and further expand its overseas territory.

National business daily synthesisAnnouncement of BYD Auto and Listed Companies

Cover image source: BYD

　　BEIJING, Oct. 15 (Reporter Wu Tao) Recently, it was reported that some users’ mobile phone numbers were "nicknamed" overnight, and they needed to pay extra minimum charges in 39 yuan, just because the last number was "8".

　　There is such an operation? What number is a "good name" and what is the current market situation of "good name"? The reporter conducted an investigation into this.

　　Operator’s latest response to "being nicknamed"

　　Recently, some media reported that Lan Xiaoyue, a user of Guangdong Telecom, used the number for several years and was suddenly "nicknamed".

　　"The staff told me that my number ends with 8 and belongs to ‘ The nickname ’ In addition to paying the monthly primary and secondary card package fee of 199 yuan, the secondary card also needs to pay the minimum consumption in 39 yuan. " Lan Xiaoyue said.

　　As of press time, the reporter of Zhongxin.com has not received a response from China Telecom.

　　In Zhejiang, similar things were reported by the media. Wang Nan, a local mobile user, found that although his "nickname" contract expired in three years, the minimum consumption limit would not end until 2099.

　　However, China Mobile told the reporter of Zhongxin.com that after investigation, none of Zhejiang Mobile’s "nickname" users was called "Wang Nan". "The reporter in the above article can’t provide the customer’s mobile phone number, so it can’t be further verified."

　　The threshold of "nickname" is low, and what is a "nickname" business has the final say.

　　With an "8" at the end, is it a "pretty name"? This reflects a feature of the "beautiful name" market, that is, the threshold of the "beautiful name" market is very low, and it is up to the merchants to decide which numbers are "beautiful names".

　　According to the survey, in addition to the well-known numbers with "888" and "666", some businesses, such as "199****2772", are regarded as "pretty numbers", according to their explanation, because they conform to the rules of the suffix "ABBA".

　　The suffix "178" means "hair together", the suffix "168" means "hair all the way", and the suffix "1349" is a geomantic number, all of which belong to "beautiful names".

　　In short, all kinds of numbers have become interesting in the mouth of merchants, "showing identity, full face and appreciation at guaranteed price" are all sales words of merchants.

　　However, some users said in an interview with Zhongxin.com, "If it weren’t for the explanation of the merchants, I couldn’t see some numbers ‘ Liang ’ Where is it? "

　　Almost all the "pretty names" have set a low monthly minimum consumption. Image source: A screenshot of an operator in official website

　　Want a "pretty name", the price is not small, and you have to spend a lot every month.

　　It doesn’t matter if you can’t see it, it doesn’t affect the popularity of the "beautiful name" market. On the official website of the operator, there are basically no numbers with the tail number format of "AAA" (that is, the tail number is three identical numbers); Don’t even think about the suffix "1314".

　　Moreover, it is not easy to get a "beautiful name", and it is even harder to raise it. Because almost all "beautiful names" have pre-stored phone bills and minimum monthly consumption restrictions.

　　For example, the number "199****3030", even if it is not "beautiful", should be pre-stored in 400 yuan, and the minimum monthly package consumption should be 99 yuan.

　　"It’s not expensive, so the ending number is ‘ AAA’ Yes, the minimum monthly package is 199 yuan. " Some merchants told the reporter of Zhongxin. com.

　　The minimum consumption of such packages basically exceeds the per capita monthly consumption quota announced by operators. Taking China Mobile as an example, its financial report shows that the monthly household income (ARPU) in 2017 was 57.7 yuan.

　　What’s more, if you want a "beautiful number", you not only need to pre-store the phone bill and set the minimum consumption, but also need a "number purchase fee" or a "number selection fee".

　　Different from the basic operators, many communication businesses openly sell "nicknames", and they don’t clearly mark the price, so they have to talk privately one-on-one.

　　Recently, the staff of a communication store on Tmall revealed to the reporter of Zhongxin. com that the price of the card number ending with "AAA" is basically more than 1,000 yuan.

　　Take "177 * * * * 555, China Telecom number and Beijing as an example, the external selling price is 1218 yuan, of which 720 yuan is the prepaid phone bill, which means that the remaining 498 yuan is the" number purchase fee ",and the minimum monthly consumption of this number is 199 yuan.

　　It is illegal for telecom operators to sell "beautiful names"

　　The Measures for the Management of Telecommunication Network Code Number Resources issued by the Ministry of Industry and Information Technology stipulates that after obtaining the right to use the code number, the telecommunication business operator shall not charge the user the selection fee or occupation fee. If there is any violation, the Ministry of Industry and Information Technology may give a warning according to the seriousness of the case and impose a fine of more than 5,000 yuan and less than 30,000 yuan.

　　The above measures also stipulate that the Ministry of Industry and Information Technology can take back the allocated code number resources if it transfers or leases the code number resources or registers the code number as a trademark.

　　Why did this happen?

　　Some operators who did not want to be named told the reporter of Zhongxin. com that at present, it is difficult for consumers to obtain "nicknames" through normal channels and they need to go to the agency market to buy them at a high price; On the other hand, criminals will also hoard numbers and speculate at high prices, resulting in a waste of number resources.

　　"The communication industry does not specify what is ‘ The nickname ’ But some popular or memorable numbers have market value in themselves. "

　　"Operators will not charge users ‘ Selection fee ’ , will be different levels ‘ The nickname ’ Corresponding to different tariff packages for customers to choose from, it is also to make high-quality resources really put on the market to avoid being hoarded and profited by a few people. " The above person said.

　　Fu Liang, an independent analyst in the communications industry, said that operators’ numbers are all applied for by number segments, including "pretty numbers", ordinary numbers and even "difference numbers", but all of them require operators to pay.

　　"Therefore, when reselling the right to use, operators will be interested in ‘ The nickname ’ Make provisions such as prepaid phone bills and monthly minimum consumption restrictions to achieve a balanced income and expenditure. " (End)

　　China car companies are accelerating their entry into the Southeast Asian market.

　　According to the Malaysian National News Agency, Geely, a China automobile manufacturer, will invest 10 billion US dollars to turn Tanjung Malin, Perak, Malaysia into the largest automobile city in the region. Malaysian Prime Minister Anwar bin Ibrahim said that Geely conveyed this plan to him in a letter, and this investment will create thousands of jobs in Malaysia.

　　Actually,It has been laid out in Malaysia for a long time. In 2017, Zhejiang Holding Group acquired a 49.9% stake in Proton Automobile, Malaysia’s "national automobile brand", which promoted Proton Automobile to become a profitable enterprise in the past three years from an enterprise with an annual loss of nearly 2 billion.

　　Behind the plan to build a "motor city" in Malaysia, it is also a new stage for China car companies to go to sea. Zhang Xiaorong, president of the Institute of Deep Science and Technology, said in an interview: "Now it is the initial stage of China’s automobile export, and in the future it will be transferred to the stage of investing in production and developing industrial chain in local countries."

　　Geely has been deeply involved in Malaysia, and once went "two-way" with Proton.

　　According to reports, Geely plans to invest 10 billion US dollars to make Tanjung Malin, Perak, Malaysia the "largest automobile city" in the region.

　　Tanjung Malin is the location of Proton Automobile Factory, and Geely and Proton Automobile achieved "two-way trip" many years ago. In 2017, Geely Automobile and Malaysia DRB-HICOM Group formally signed an agreement, and Zhejiang Geely Automobile Holding Group acquired 49.9% shares of Proton Automobile, a subsidiary of DRB-HICOM Group, and Geely Automobile also became the exclusive foreign strategic partner of Proton Automobile.

　　China-ASEAN, which the reporter recently participated in.In the automobile industry cooperation forum, Wang Huaibing, CFO of Proton Automobile, said that Geely held hands with Proton Automobile to lay out Southeast Asia and chose one.Machine. Catch up with the country "At that time, the launch of Geely Automobile 3.0 also promoted the upgrading of China automobile industry, which laid a good foundation for Proton’s subsequent success.

　　According to Wang Huaibing, Proton Automobile was founded in 1983 by Malaysian Prime Minister Mahathir at that time and has a history of 40 years. In 1985, Proton rolled off the assembly line with its first "SAGA" car. After that, Proton became the sales champion in Malaysia for 20 years. At the peak, its market share once reached 60%. It was a national car in Malaysia and a "national treasure brand". However, after many tests, Proton’s car sales once declined. By 2018, the entire market share once fell to 10%, ranking only the fourth in Malaysia.

　　In the early days of Geely Automobile’s shareholding in Proton, Proton Automobile faced the dilemma of "four highs, four lows and more than two". "Four highs" refers to high cost of spare parts, high loss, high product inventory and high personnel expenses; "Four lows" refers to low sales, low quality, low brand reputation and low staff morale; "Liangduo" refers to multi-race, culture, politics (Malays, Chinese, Indians) and multi-nature (state-owned enterprises, private enterprises, transnational joint ventures and private enterprises).

　　"Malaysia is a multi-ethnic cultural and political background. Proton is a state-owned enterprise in Malaysia, and Geely is a private enterprise. It is not easy for us to set up such a multinational joint venture. The situation of reform is quite complicated." Wang Huaibing said.

　　Wang Huaibing said that shortly after the establishment of the joint venture company, Proton Automobile set up eight cross-functional groups with about 200 participants, one of which was "How to solve the problem of the canteen". "This problem seems very small, but if the canteen is not improved well, how can we make a complicated car and improve the level of products and services? It is precisely by mobilizing local employees to find and solve problems together and promote problem-oriented reforms that we can unify our thinking and integrate Proton into Geely’s culture. " He said.

　　At present, Geely and Proton Automobile have achieved "win-win cooperation". According to reports, Proton’s automobile exports ranked first in Malaysia for two consecutive years and have been exported to 13 countries. In terms of price, the average selling price of Proton Motor increased by 34% from 2018 to 2022, and its brand awareness was improved. From a company with an annual loss of nearly 2 billion to a company that has achieved profitability in the past three years.

　　China car companies have increased their sales in Southeast Asia, and their sales have been "dominated"

　　Behind Geely Automobile’s accelerated layout of Malaysian market, China car companies are constantly increasing the Southeast Asian market.

　　On May 5, Vietnamese Vice Premier Chen Honghe met with him in Hanoi.Wang Chuanfu, Chairman of the Board of Directors, negotiated the contents related to electric vehicles. Wang Chuanfu hopes that Vietnam will provide "favorable conditions" for completing the investment process, so that electric vehicles can be quickly invested in Vietnam and sold in local and other markets in Southeast Asia.

　　In September 2022, the first overseas factory landed in Thailand, and it is expected to start operation in 2024. The planned annual output of this factory is 150,000 vehicles, which will radiate the entire ASEAN market. Besides BYD,We have established factories in Thailand and Indonesia,The Thai factory has been put into production for two years, and many China car companies have accelerated their influx into the Southeast Asian market.

　　Why do China car companies flood into Southeast Asia? Because their cars are selling like hot cakes in the Southeast Asian market. The relevant person in charge of BYD told reporters that in November 2022, BYD’s ATTO3 (Yuan PLUS) was listed in Thailand, which triggered local users to "snap up in the middle of the night".

　　Tang Zhimin, founding dean of the International College of Chia Tai School of Management in Thailand and director of China ASEAN Research Center, said that among the top five models of pure electric vehicles in Thailand in 2022, China brand occupied four seats, namely, Great Wall ORA Good Cat, MG EP and MG ZS EV of Chia Tai SAIC, and ATTO3 of BYD. In the first quarter of this year, the market share of BYD ATTO3 (pure electric) was as high as 37.5%, and the sales of Nezha V, ORA Good Cat and MG were also among the best.

　　Published by CanalysChina’s automobile export core areas are gradually shifting from "irregular areas" such as Africa, Central Asia and South Asia to "economically developed" and "automobile industry developed areas" such as Europe and Southeast Asia.

　　Canalys predicts that in the next 10 years, the overall automobile market in ASEAN will enter a period of rapid development. Although at this stage, NEV(New Energy Vehicle,The penetration rate is lower than other mainstream countries, but countries represented by Thailand and Vietnam have continuously introduced support policies for new energy industries and increased infrastructure investment. The combination of China-ASEAN Free Trade Area construction and RCEP and other favorable factors will further promote the penetration rate of China automobile products, especially new energy products, in the Southeast Asian market. It is estimated that by 2025, the penetration rate of China automobile products in Southeast Asia will increase rapidly from 2.6% in 2022 to 12.8%.

　　Entering the new stage of supply chain going to sea, facing the competition from Japanese and Korean car companies

　　Judging from the automobile export, China is already hitting the "No.1 in the world". According to the data of China Association of Automobile Manufacturers, China’s automobile exports continue to maintain rapid growth. In the first half of this year, automobile enterprises exported 2.14 million vehicles, up 75.7% year-on-year, and it is expected to become the world’s largest exporter this year.

　　However, the export data only reflects the strength of products going to sea. Compared with Japanese, Korean and European and American automobile giants setting up factories in various countries to promote "manufacturing going to sea", the progress of China automobile enterprises going to sea is still in the initial stage.

　　In the Southeast Asian market, Japanese car companies are facing strong competition from Japanese and Korean car companies. Wang Huaibing said that ASEAN is dominated by Japanese cars, accounting for about 80%. Because Japanese cars have been deeply cultivated in Southeast Asia for many years, they are supplied from upstream and downstream.A complete financial layout has a "monopoly position" on local industrial policies, including the ASEAN market.

　　At present, the automobile market in Southeast Asia is mainly occupied by Japanese cars such as Toyota and Korean car giants such as Hyundai and Kia. According to the data of Indonesia Association of Automobile Manufacturers, in 2022, the sales volume of cars in Indonesia exceeded 1.01 million, of which Japanese cars accounted for 92% of the market share, and Toyota ranked first with sales volume of 329,500. According to the data of Vietnam Automobile Manufacturers Association, in 2022, the top five brands among its member companies were Toyota, Hyundai, Kia, Mitsubishi and Mazda, all of which were Japanese and Korean car companies.

　　"At present, China has only surpassed Japan in terms of the number of automobile exports, but there is still a considerable gap between China brand and Japanese cars in terms of global sales of Japanese cars under full-scale statistics. Japanese brands still have strong local advantages in global layout of industrial chain, regional guarantee of supply chain, sales strategy and channel innovation. " Independent international strategyChen Jia said in an interview with reporters.

　　Wang Huaibing said: "The internationalization of China enterprises can be divided into three stages: going out, going in and going up. Going out is very simple. As long as you have products and technology, you can find an agent locally. But this kind of going out is also easy to’ walk back’ and has no foundation. Going in’ means not only having products and technology, but also having management and culture to go out to sea. For example, Geely’s hand in hand with Proton is a model of finding partners in the local area to fully "go in". In addition to the above-mentioned elements,’ going up’ must have brand and local manufacturing R&D capabilities, which is also an international trilogy. "

　　"China enterprises going out to sea, upgrading from the original simple trade in goods to the output of the whole value chain of industrial chain and supply chain, should be the general trend of future development." Wang Huaibing said.

　　Chen Jia believes: "Geely’s construction of a $10 billion automobile city in Malaysia is definitely a major event for China car companies to go to sea, but there is still a long way to go to truly become a benchmark for China car companies to go to sea in a new stage. In addition to huge investment, Geely also needs to develop a new industrial chain mode, a new global supply chain network, a new operating cost control system and a localized marketing network system. "

China Net Auto May 28th Recently, BYD officially released a set of preview pictures of brand-new models, and officially named it "Brand-new Qin". The internal code name of this car was HD before, and now it is named Brand-new Qin, which means that it is the replacement of Qin models. It is reported that the new car will be listed during the year.

On the front face, the new car adopts BYD’s latest Longyan family design style, but the exaggerated hexagonal mesh grille has been stretched horizontally, and the visual effect is more majestic. Matrix headlights with linear daytime running lights have excellent effect.

The rear part is consistent with the shape of the front face. The taillights are three-dimensional in shape and sharp in style. In addition, the taillights of the new car did not adopt BYD’s penetrating taillight design, which improved the recognition of the new car. Other information about the model has not been officially disclosed yet, and we will continue to pay attention to it in the future.

Immunotherapy has become a trump card in the fight against cancer! By stimulating the ability of our immune system to fight cancer, it sets up a brand-new principle for cancer therapy, which can be said to be a milestone in the process of human struggle against cancer!

In addition to the well-known immune checkpoint inhibitors, CAR-T therapy is undoubtedly the leader in the field of global cancer cell immunotherapy. Because of the successful research and development of CAR -T therapy, it has created a miracle of "curing" cancer. This treatment method has been proved to induce significant reactions-even patients with advanced cancer whose survival time is only a few months can be completely eradicated, and in some cases the strong response lasts for months or even years. For example, Emily, a leukemia girl, was dying after being diagnosed at the age of 5, but now she has been successfully cured by CAR-T cell therapy for nearly 10 years, and she has become the spokesperson of this epic therapy and has been recorded in history.

Emily, a leukemia girl, declared cancer-free for 9 years.

CAR-T therapy brings changes to global cancer treatment.

In recent years, there has been a worldwide upsurge in the research and development of CAR-T therapy, because whoever makes CAR-T therapy technology with better curative effect and lower side effects will undoubtedly take the lead in eating the first crab and open a new era of tumor immunotherapy. At present, six CAR-T therapies have been approved by FDA, and two CAR-T products have been listed in China, and seven CAR-T therapies have been approved worldwide!

Unfortunately, CAR-T therapy is only approved in hematological tumors at present, because the tumor cells of hematological tumors have ancestral targets, such as CD19 (only existing in tumor cells but not in normal cells), and we can easily rely on this target to lead CAR-T cells to find cancer cells and eliminate cancer.

However, there is no such obvious target in solid tumor that exists only in cancer cells but not in normal cells. Therefore, the clinical efficacy of CAR-T cells in the treatment of solid tumors has been poor. The medical community has always hoped that CAR T cells can develop new specific targets for more solid tumors!

The rise of new anti-cancer forces! Six solid tumor CAR-T therapies bring unprecedented survival breakthrough!

At present, with the change of CAR-T algebra, CAR-T has obviously improved in proliferation and cytokine release, and this technology has finally broken the ice. More and more clinical trials have begun to try to use CAR-T in the treatment of solid tumors, and patients with advanced solid tumors are welcoming warm spring!

Representative antigen targets include:

Mesothelin for the treatment of mesothelioma, pancreatic cancer, ovarian cancer and lung cancer;

CEA is used to treat lung cancer, colon cancer, gastric cancer, breast cancer and pancreatic cancer;

MUC-1 is used for treating liver cancer, lung cancer, pancreatic cancer, colon cancer and gastric cancer;

GPC3 for the treatment of liver cancer;

EGFＲvII is used to treat glioma and head and neck tumors;

B7-H3, used for treating Ewing sarcoma, rhabdomyosarcoma, nephroblastoma, neuroblastoma and medulloblastoma, as well as brain stem tumor (DIPG) which is particularly difficult to treat;

PSMA, used for prostate cancer, etc.

Claudin18.2, used for gastric cancer, pancreatic cancer, etc.

….

Application of 01GPC3 CAR-T in liver cancer

Liver cancer is the second leading cause of cancer death in the world (accounting for 8.2% of the total). Although great progress has been made in diagnosis and treatment in recent years, the effect of current targeted and immunotherapy is limited, and better treatment schemes are urgently needed in clinic.

GPC3 is a carcinoembryonic antigen, which is involved in cell proliferation, differentiation, migration and apoptosis. What excites researchers is that GPC3 protein is almost not expressed in 21 normal tissues such as heart, liver, spleen, lung and kidney, but it is expressed in 70-80% hepatocellular carcinoma and lung squamous cell carcinoma. GPC3 is considered as a promising tumor immunotherapy target because of its tumor specificity. The good news is that there are monoclonal antibodies, double antibodies, therapeutic vaccines and GPC3 CAR-T therapy for this target, which have shown great potential in liver cancer.

In 2020, good news came from the Chinese team: the results of Phase I clinical research on the treatment of advanced hepatocellular carcinoma (HCC) with the second generation CAR-T cell therapy targeting GPC3 were released, and the research results were published in the international heavy oncology journal Clinical Cancer Research, which caused a sensation. It is worth mentioning that this is the world’s first clinical trial targeting GPC3 CAR T cells to treat hepatocellular carcinoma, and the research results of Chinese scientists once again shine on the world stage.

In this newly published study, 13 patients with advanced liver cancer were enrolled (from December 2015 to July 24, 2019).

The results show that:

Of the 13 subjects, 2 obtained partial remission (PR);

The 3-year, 1-year and 6-month survival rates were 10.5%, 42.0% and 50.3% respectively.

The median survival time (OS) was 278 days (95% CI: 48,615 days).

Two patients with advanced liver cancer, numbered 3 and 13, were very lucky. After receiving GPC3 CAR T treatment, the lesions were significantly reduced, and some of the target lesions even subsided!

The good news is that the new T-therapy has officially started to recruit patients in China. At present, several well-known cancer hospitals in China have taken the lead in clinical research, and some patients have successfully entered the group through the application of the global oncologist network.

In addition, at the virtual annual meeting of the American Society of Clinical Oncology (ASCO) in 2021, CARsgen Therapeutics presented a new fourth-generation chimeric antigen receptor T (CAR-T) cell ORI-CAR-001 (NCT03980288) based on the second-generation CAR-T.

The fourth generation of CAR-T cells can secrete transgenic cytokines when targeting CAR signal transduction in tumor tissues after additional engineering modification. Therefore, in addition to direct anti-tumor attacks, they can also trigger T cells to eliminate antigen-negative cancer cells in the target site, which is more effective!

The preliminary results of this study show that the safety and effectiveness of Ori-CAR-001 in patients with GPC3 positive recurrent/refractory HCC are encouraging.

By March 10th, 2021, 11 patients had participated in this study. All subjects were advanced hepatocellular carcinoma, and previous treatment methods (including chemotherapy, TACE and targeted therapy) failed.

The results showed that among 9 evaluable subjects, 4 achieved partial remission (PR), 3 achieved disease stability (SD) and 2 developed disease progression (PD). The objective remission rate was 44.4%, and the disease control rate reached 77.8%.

It is worth mentioning that the tumor volume of subject 007 decreased by more than 80% one month after cell therapy infusion! Subject 012 also saw a good tumor response. He had advanced and diffuse large HCC and joined the study after radiotherapy, targeted drugs and 12 TACE failures. On the 28th day after CAR-T cell infusion, the diameter of the target tumor lesion decreased from 133 mm at baseline to 9 mm, a decrease of more than 93%. At present, the subject is being evaluated at the third month after CAR-T cell infusion, and MRI scan shows that the tumor has almost completely subsided!

02

Application of claudin18.2 CAR-T in gastric cancer and pancreatic cancer

Claudin 18.2 is a target of pantumor, which is expressed in many epithelial tumors, especially in gastric cancer and pancreatic cancer. In gastric cancer or gastroesophageal junction cancer, the high expression of Claudin 18.2 was detected in as many as 60% patients. Based on this, researchers in China developed the first CAR-T cell therapy for Claudin18.2 –CT041.

The preclinical research results of CT041 cells in the treatment of gastric cancer show that gastric tumors can be completely eliminated in mouse models without off-target toxicity.

Based on excellent preclinical data, China took the lead in developing a multi-center, open-label phase I clinical study of Claudin 18.2 CAR-T cells in the treatment of patients with digestive system tumors, including dose escalation stage and dose expansion stage. The main purpose was to evaluate the safety and tolerance of CT041, and the secondary purpose was to evaluate the efficacy and pharmacokinetics.

It is worth mentioning that all the patients in the group have received second-to third-line treatment, Claudin 18.2 is moderately highly expressed, most of them have multiple organ metastases, and nearly half (42.9%) of them have also received PD-1 treatment, which is extremely difficult to treat clinically.

Experimental design:

By April 8, 2021, 37 patients had received CT041 infusion and completed the evaluation for at least 12 weeks, including 28 cases of gastric cancer/gastroesophageal junction cancer (GC/GEJ), 5 cases of pancreatic cancer (PC) and 4 cases of other digestive system tumors. The dose levels of CAR-T cells were 2.5× 10, 3.75× 10 and 5.0× 10, respectively.

The results show that:

The target lesions of 31 patients were reduced in different degrees. The overall objective remission rate (ORR) was as high as 48.6%, and the disease control rate (DCR) was 73.0%.

Source CARsgen Therapeutics

Among them, the objective remission rate (ORR) and disease control rate (DCR) were as high as 61.1% and 83.3%, respectively, in 18 patients with gastric/gastroesophageal junction cancer who failed in at least second-line therapy (including 8 patients who had received PD-1) at the dose of 2.5× 10 CAR-T cells. MPFS is 5.6 months and mOS is 9.5 months.

Source CARsgen Therapeutics

In terms of safety, CT041 is generally well tolerated. No treatment-related deaths or immune cell therapy-related neurotoxic syndromes (ICANS) were reported. About 95% patients experienced CRS, all of which were Grade 1 or Grade 2.

The reason why domestic experts agree that this data is excellent is because historical data show that the effective rate of chemotherapy is only 4% ~ 8% and the effective rate of anti-PD-1 antibody is only 11% for patients with gastric/gastroesophageal junction cancer who failed at least the second-line treatment in the past, and the objective remission rate of CT041 for second-line treatment failure, even after PD-1 treatment failure, can be as high as 61.1% (which means 61.1% in the late stage)

In addition to the above data, the treatment of two patients who achieved objective remission was also announced:

01

Patient 04, 53-year-old male.

Source CARsgen Therapeutics

Advanced gastric cancer with liver, lung, bone metastasis and multiple lymph node and peritoneal metastasis has received two kinds of systemic therapy, including PD-1 antibody, CLDN was 18.260% (3+). After CAR-T therapy, the tumor shrank by nearly 50% and remained in remission for 32 weeks.

02

Patient 08, 57-year-old female.

Source CARsgen Therapeutics

GC has peritoneal metastasis and Mary Joseph’s nodule (a nodular lesion formed by the metastasis of malignant tumor to the umbilical region). It has received 3-line therapy including PD-1 antibody and CLDN18.2 80%(2+) before, and achieved partial remission after CAR-T treatment, and continued to respond for more than 56 weeks.

03

Application of gucy2car-t in colorectal cancer

C(guanylyl cyclase C (GCC/GUCY2C) is a member of the receptor guanyl cyclase family, and it is the receptor of guanyl, guanyl and Escherichia coli enterotoxin, and plays a key role in the liquid and ion homeostasis of gastrointestinal tract. About 80% patients with colorectal cancer have positive expression of GCC. The expression of GCC in normal tissues is limited to the top of intestinal epithelial cells, but not in other tissues and organs. In recent years, it has been found that GCC is stably expressed in primary colorectal cancer cells, but abnormally highly expressed in metastatic colorectal cancer cells, which is considered as one of the specific marker molecules of metastatic colorectal cancer.

GCC19CART is an autologous CAR-T therapeutic product, which is the leading solid tumor therapy for the treatment of relapsed and refractory metastatic colorectal cancer (R/R mCRC). GCC19CART specifically targets and eliminates cancer cells that express colorectal cancer tumor marker GCC. According to public information, the clinical trial of 35 patients with relapsed and refractory colorectal cancer conducted by GCC19CART in China has achieved initial results. In the early clinical trial (IRB) initiated by China, the researchers enrolled 35 patients with advanced colorectal cancer. Among the 8 patients who received a dose of 2×106 GCC19CART cell/kg in the dose climbing test, an objective remission rate of 50% was observed.

On April 19th, 2022, Shanghai Stensai Bio announced that its solid tumor CAR-T product GCC19CART was granted fast-track qualification by the US Food and Drug Administration (FDA). Have to say, this honor makes China CAR-T therapy take another solid step on the road of overcoming solid tumor, which is worth looking forward to!

04

Mesothelin CAR-T therapy

Mesothelin is a cell surface glycoprotein, which is highly expressed in many tumors, such as malignant pleural mesothelioma, pancreatic cancer, ovarian cancer and part of lung cancer, but poorly expressed in normal pleura, peritoneum and pericardium. Preclinical studies show that CAR-T cells targeting mesothelin have potential anti-tumor effects.

The latest results of mesothelin CAR-T therapy published by the University of Pennsylvania at the American Society of Clinical Oncology in 2019 showed that six patients with refractory metastatic pancreatic ductal adenocarcinoma were successfully enrolled, and all patients had received two or more treatments. These patients were infused with mesothelin CAR T cells three times a week for a total of nine doses. The results showed that there were 2 patients with stable diseases, and their progression-free survival time was 3.8 months and 5.4 months.

Therefore, this new therapy has biological activity in patients with pancreatic cancer, and this study is still in clinical trials (NCT03323944). At present, a large number of mesothelin CAR-T clinical studies have been carried out in China, and preliminary results have been achieved. In mouse experiments, the tumors of advanced ovarian cancer mice receiving the new mesothelin CAR-T therapy have rapidly subsided. At present, this technology is recruiting all kinds of patients with advanced solid tumors in China. Those who want to participate can apply to the Medical Department of the Global Oncologist Network.

Spring is blooming, and more new treatments are on the way!

Before the advent of cell therapy, solid tumors, including advanced gastric adenocarcinoma and pancreatic cancer, were usually treated by surgery, radiotherapy and chemotherapy. Among them, the incidence of gastric adenocarcinoma accounted for 95% of gastric malignant tumors, and pancreatic cancer was the most malignant tumor among common tumors. The median survival rate and 5-year survival rate were far lower than other tumors, so it was called "the king of cancer". However, most patients will have local recurrence or metastasis after operation. In addition, this kind of malignant tumor is not sensitive to radiotherapy and chemotherapy. Therefore, based on the current standard therapy, the treatment effect is not ideal, and the prognosis is extremely poor. The emergence of immunotherapy will bring hope and miracle for long-term survival to more advanced patients.

We firmly believe that after the introduction of a perfect cellular immune regulatory system, the country will open the door of cellular immunotherapy to benefit more cancer patients, and our country’s cellular immunotherapy will also enter the international stage!

On April 22, 2010, in the New China Exhibition, some exhibition cars from auto china entered the museum.

　　　　 The 11th beijing international automotive exhibition 2010 will be held in the new China International Exhibition Center (Tianzhu) and the old China International Exhibition Center (Jing ‘anzhuang) from April 25th to May 2nd, 2010.

　　　　 The new national exhibition mainly displays domestic and foreign passenger cars and commercial vehicles. The exhibition date of the old national exhibition is April 23-April 27, which mainly displays domestic and foreign auto parts and related products. This year’s auto show has more than 2,100 exhibitors from 16 countries and regions, with an exhibition area of nearly 200,000 square meters.

The schedule of this auto show:

1. The new China International Exhibition Center.

April 23 and April 24The exhibition news day is dedicated to receiving visits and interviews from domestic and foreign media reporters. The press day only accepts media personnel and exhibitors with exhibition press cards. Daily exhibition time: 9: 00-18: 00.

April 25th and 26th., professional visit day, daily exhibition time: 9: 00-17: 00

27 April-2 May, public visit day, exhibition time: 9: 00-17: 00, of which, the exhibition time on May 1st is 9: 00-18: 00. Exhibition time on May 2nd: 9: 00-15: 00,

2. Old China International Exhibition Center.

23 April-27 April 2010Exhibition time: 9: 00-17: 00.

The visit time is from 9: 00 to 15: 00 on April 27th. Professional visitors are admitted free of charge after registration.

3. Schedule of main activities:

On April 24th, from 12: 00 to 17: 00, a public welfare activity will be held in the new National Exhibition Hall.

At 10: 00 am on April 25th, the opening ceremony of this auto show was held in the South Landing Hall of the new National Exhibition Hall.

Produced by | Sohu Auto Sohu New Car

Author | Li Wei

Editor | Ma Liang

I remember that when I was a child, I read The Three Kingdoms at the beginning: "Great things in the world must be separated if they are combined for a long time, and the combination of Wei Lai, Ideal and Tucki seems to have become the new" Three Kingdoms "for new forces to break into the high-end luxury car market. Of course, this time we are not talking about their "combination", but about their own "points". Recently, both Weilai and Tucki have exposed their second brands with lower positioning, and Ideality seems to want to open up new product lines through the less successful MEGA, and has plans to launch low-priced models. Then, why are these new forces in a hurry to open the "trumpet"?

● The turn of new forces to build cars

Unlike those traditional China brands that have gradually developed from low-end to high-end markets, the new car-making forces we all talk about usually choose to enter the market with mid-to high-end products, which not only means that they can make more rich profits, but also help the innovation and application of cutting-edge technologies, and also establish their own higher brand image and tonality.

The most typical one is Weilai, whose target is always the German luxury giant BBA (Mercedes-Benz, BMW, Audi), and we can also see Weilai’s exhibition hall in the middle and high-end business districts of major cities. Judging from the sales achievement of 160,000 yuan in 2023, Weilai’s brand image has initially stood firm in the middle and high-end market (300,000-500,000 yuan), but compared with the huge domestic base, there is still huge room for improvement. So we saw the second brand that has announced its official name-"Ledao".

According to the previous news, "Ledao" will be released in the first half of May, and it will focus on the new energy family car market of 200,000-300,000 yuan. All models will be developed based on NT3.0, the third generation technology platform of Weilai. Judging from the spy photos previously exposed, Ledao’s first model is a pure electric slip-back SUV, or it will be named L60, which will be unveiled in the second quarter of this year, listed in the third quarter and delivered in the fourth quarter.

Different from Weilai’s existing products, Ledao L60 (tentatively named) is mainly based on Model Y. The official revealed that the cost of this car is about 10% lower than that of Tesla Model Y, and the price has an advantage; With the listing of Xiaomi SU7, it seems that this model has more late-comer advantages in pricing. At the same time, Weilai has also planned about 60kWh and 90kWh versions for this car, and will be compatible with Weilai’s power exchange service.

Not only that, but in addition to Ledao, Weilai will also launch the third brand-Firefly. The spy photos of the first model have been exposed. It is said that it also focuses on exchangeable electricity. It is estimated that the price will be controlled within 200,000, and it will be produced in Hefei, Anhui, with high cost performance.

Unlike Weilai’s high-profile brand image, Tucki opened its early market through Tucki G3, whose price is relatively close to the people. However, judging from the recent product layout and planning, with the listing of Tucki X9, whose price has exceeded 400,000 yuan, the focus of the brand has shifted to higher-priced models. Judging from the sales achievement of 142,000 vehicles in 2023, Tucki can’t achieve scale effect with existing products, so it is imperative to launch new brands.

In fact, Tucki officials have confirmed the existence of the new brand, which is expected to be released at the Beijing Auto Show. Combined with the previous news, the brand expects the project code to be "MONA", which is positioned at the level of 100,000-150,000 yuan, and the first product will be listed in the third quarter of 2024. Xpeng Motors will integrate the technical foundation of Didi Chuche in MONA project, and add the intelligent software capabilities such as XNGP and intelligent cockpit developed by Xpeng Motors, and the related products will be manufactured in its own production base in Xpeng Motors.

It is worth mentioning that Volkswagen has also signed a technical cooperation agreement with Tucki, and announced that it will jointly develop two intelligent networked vehicles for the China market. Tucki will provide the platform and technology, and Volkswagen will do engineering research and development, design and manufacture. The first two models have been confirmed to be listed in 2026, and the first product will be an SUV. Although this is not a new brand, it is also a new change in the development direction of new forces compared with traditional overseas car companies.

At present, LI has not made it clear whether it will launch multi-brand strategy, but from its product planning, it can smell the breath of exploring the middle market. Ideally, the price of the upcoming L6 model is expected to be lower than the 300,000-yuan mark for the first time, changing the pricing tradition of all previous models to more than 300,000 yuan. From 450,000 yuan for L9, 560,000 yuan for MEGA, to less than 300,000 yuan for L6, Ideal is also trying to leverage price to incite a broader market demand.

In fact, from the above summary of "Wei Xiaoli", it is not difficult to see that with the gradual maturity of the new car-making forces, the greatest significance of sub-brands lies in their ability to break the thinking framework of existing brands, enrich their own product matrix, and capture more users with different consumption levels through differentiated competition. After all, high-end luxury and pragmatism are contradictory, and it is impossible for 20-year-old users and 50-year-old users to have the same car demand. These may be one of the reasons why new power brands launch new brands, but there may be others in combination with the current market. ….

The road to survival under "involution"

At present, the new energy market of 150,000-300,000+concentrates the fiercest competitive firepower of domestic new energy vehicle companies, including new power vehicle companies, traditional China brands, and more and more new car-making players: with the help of Huawei’s blessing, the world has moved to the front desk, with sales exceeding 10,000 in three months; The admission of Xiaomi SU7 at least taught the car companies a lesson in marketing; The practice of creating brand-new brands and grafting mature supply chains and production lines has also been played by Changan, SAIC, Geely, Great Wall and BYD. As for the traditional multinational car giants such as Volkswagen, GM, Toyota and BBA, they will naturally not miss the domestic electric vehicle feast, and continue to increase the pace of launching new cars in the field of smart electric vehicles.

As for the mature "Wei Xiaoli", it seems that it has reached the "year of no doubt", which not only lacks some new-comer spirit, but also faces the reality of survival. It is well known that the new forces making cars are losing money. In 2023, Weilai’s net loss reached 20.72 billion yuan, an increase of 6.283 billion yuan over the previous year. Xpeng Motors’s net loss in 2023 was 10.38 billion yuan, up 13.6% year-on-year. Due to the failure to achieve the scale effect, new car-making enterprises such as Weilai and Tucki have been unable to achieve profitability, which also makes Weimar, who has gone bankrupt, and Gao He, who is still lying in the ICU, smile at each other. ….

Therefore, the underlying reasons for Weilai and Tucki to launch sub-brands are to reduce costs, reduce losses and promote the profitability process. Once the value chain of a new car enterprise is formed, the marginal cost of launching a new brand is relatively low, and the existing technology, platform, production, marketing and channel service capabilities can be fully utilized. Covering multiple market segments through multiple brands can effectively increase sales and market share, so as to improve financial performance quickly.

In fact, both Tucki and Weilai have said before that they expect to turn losses into profits or break even in 2025, which means that Weilai and Tucki have only two years to achieve their profit targets, and marching into the lower-priced market with a larger share has become their common choice.

Can the multi-brand road really work?

I have to say that it is not an easy task to run many brands. If we want to make enough differentiation between different sub-brands, it means that car companies need to have sufficient technical reserves, otherwise it will inevitably form mutual relations between sub-brands. For intelligent electric vehicles, at least there should be enough separation in the core areas of vehicle platform, three-electric system, intelligent cockpit and automatic driving. How to create differentiation with as little capital investment and limited technical reserves within a limited pricing interval is a challenge they have to face.

In addition, with the cost reduction, for Weilai, a new force with high investment in service and power exchange capacity as its selling point, it is bound to choose between price and selling point. And the third brand of Weilai, which has lost its service and power exchange, depends on what to kill the quartet in the sinking market?

At the same time, positioning different series under the same brand and launching brand-new sub-brands can certainly establish a complete product matrix, but it also means that no matter from marketing, marketing channels, or even car owners’ community apps, we must start from scratch. The increased operating costs behind it will also be a big burden.

Say at the end:

The strategy of "having more children and fighting" once pursued by China brand seems to be not practical in today’s market, and it is obviously not the will of the new forces that are maturing. Therefore, the second brand under the "prenatal and postnatal care" seems to be a more secure way. After all, with the increase of the penetration rate of new energy vehicles, it will be more and more difficult to eat the world through one or two explosive products, and the new energy market will blossom like the current fuel vehicle market.

Cctv newsRecently, at the press conference on the development of industrial communication industry in the first half of the year held by the State Council Office, Xin Guobin, Vice Minister of the Ministry of Industry and Information Technology, gave a detailed introduction to the characteristics of new energy vehicles’ power exchange mode when answering a reporter’s question, which was clear in organization and could be called a textbook answer.

He believes that charging and changing electricity are both ways to supplement the energy of electric vehicles, each with its own advantages, its own application fields and consumer groups. At present, although new energy vehicles have made great progress, they are still in the early stage of industrial development. The technical route and business model are still being explored and changed. He suggested that everyone should support the innovative development of new technologies, new formats and new models, encourage enterprises to develop new charging and power exchange technologies, and explore the application of the mode of separation of vehicles and electricity to meet the needs of different markets.

Compared with the charging methods that you know more about, the power exchange mode also has its own characteristics. Xin Guobin can be summarized as follows.

First, the separation of vehicles and electricity can greatly reduce the cost of consumers buying cars.Now it is generally felt that new energy vehicles are relatively expensive, although the state has a subsidy policy. Moreover, the subsidy policy of this country has made it clear that the slope retreat will be completed by the end of this year. Due to the impact of the epidemic, it is decided to postpone the progress of slope retreat, and it can be extended for another period. Therefore, the separation of vehicle and electricity can greatly reduce the cost of car purchase for consumers.

Second, it can increase the convenience for consumers to travel.The time for changing batteries is even shorter than that for adding a tank of oil. Relevant comparisons show that, for example, if the power station is changed now, it takes less than 3 minutes for the car to drive in and out, and it takes 5 minutes or 8 minutes to add a tank of oil. Therefore, changing electricity is actually very convenient as long as you get used to it.

Third, the centralized monitoring, maintenance and management of batteries by battery operating companies is conducive to prolonging the life of power batteries and improving the safety of batteries.Consumers buy new energy vehicles, and many people just drive them, so the care, attention and maintenance of the vehicles are not so timely. In fact, the battery is also a very fragile component. In addition to the battery monomer, there is also the management problem of the battery pack, which requires high technical requirements and needs to be maintained and tested in time during use. Otherwise, there is a great risk during charging and one hour after charging. Once the thermal control and management are not good, deflagration may occur. Even with this problem, the spontaneous combustion rate of new energy vehicles is lower than that of traditional vehicles. Centralized management by battery operating companies can improve the safety of batteries. In fact, it is very important to change the concept. It is natural and normal for traditional cars to go to gas stations to refuel, so it should be possible for new energy vehicles and electric vehicles to change batteries and rent electricity.

The fourth is to use the difference between peak and valley electricity prices to reduce the charging cost.At present, new energy vehicles are often driven home to charge at night and charged at peak hours, so the price of electricity will be relatively high. If a battery operation company manages batteries, it can fully use the peak-valley preferential electricity price to charge, which can reduce the cost of renting batteries.

Fifth, we can consider how much electricity to rent that day according to the daily mileage.At present, the basic driving range of new energy electric vehicles is 400 kilometers, and a set of batteries in a car is six or seven hundred kilograms, which accounts for a high proportion of vehicle weight. In fact, most people don’t travel more than 50 kilometers a day. Imagine that if you want to run 50 kilometers today, you can rent 50 kilometers of batteries instead of carrying 400 kilometers of batteries, so the weight of the car will be greatly reduced and the power consumption will be greatly reduced. For the whole society, if everyone does this, it will be a great savings. If you are worried about how to rent 50 kilometers of electricity, as a battery operating company, you can do it if you want 50 kilometers and allocate 70 kilometers of electricity just in case there is a little problem.

There’s another way,It can solve the problem of difficult construction of charging piles in old communities.Now, there is still a concern for people to buy new energy vehicles. They live in an old community and need to build a charging pile. The voltage load in this community is not enough, so they can’t install it. When the charging pile company wants to install in this community, it encounters some problems, such as insufficient power load. Who will expand the capacity? Who will pay for the expansion? Therefore, it brings a series of problems. The construction of charging piles in old communities is a social problem and difficult to handle. Therefore, if the power exchange mode is adopted, this problem can be effectively solved.

Sixth, the power exchange model can also give birth to some new service formats.Nowadays, express delivery is very convenient. You can get to your side in 10 minutes by making a phone call. If the industry adopts the mode of changing electricity, engages in a tram and swims in the street, whoever proposes to change electricity must ensure that it will arrive within 10 minutes. In fact, there is no technical problem. This may give birth to some new service models.

Of course, there are still many problems to be solved to promote this power exchange mode. For example, the overall design of the vehicle, the battery box should be standardized and unified, there should be national standards, and the battery should also be standardized, whether it is soft or hard, square or cylindrical, the specifications should be standardized. In addition, the plug-in of batteries should also be standardized, which still needs further exploration.

However, from a technical point of view, there should be no major problems. Therefore, in the next step, the Ministry of Industry and Information Technology will continue to vigorously promote the construction of this charging and replacing infrastructure with relevant departments, further improve relevant technical standards and management policies, and encourage enterprises to develop battery replacement models according to usage scenarios. It will also support pilot projects in places like Beijing and Hainan to promote the high-quality development of new energy vehicles.

In this regard, some places are still moving faster, such as Beijing, where enterprises are ready to push this mode of power exchange. In some fields, such as buses in public transportation, some electric buses adopt the mode of changing electricity. In the field of taxis, some have adopted the electricity-changing mode. For example, after the taxis in Beijing adopted the electricity-changing mode, the order-taking rate increased by more than 30%, the driving mileage increased by nearly 30%, and the personal income of taxi drivers also increased by more than 30%.This is a very beneficial model for all parties.

In the next step, relevant departments will actively promote it. Xin Guobin also put forward an initiative. Welcome everyone to publicize these new things and new formats, give them more encouragement and support, let them mature at an early date, and make more contributions to the green development of the whole society.

Information Times (Reporter Cai Mujia) Jiangsu Satellite TV Travel Exploration Music Singing Healing Reality Show "Sound You Come" was launched on April 5. Recently, the program held an online film viewing conference. The chief producer of the program, Duo Xiaomeng, and members of the creative team watched the feature film together with many media reporters, and shared the core idea of the program and the creative experience behind it.

As a variety show that shows the social status of contemporary people in the form of "music+travel", "You Come" invited seven musicians, including Wilber Pan, Ar Fi, Diamond, Martial Arts, Winnie, Lil Ghost and Gao Qingchen, to start a "journey to you". In the program, they will take to the streets of cities with different customs, complete six live concerts with distinctive themes and different styles, and cure every listener with music. Establishing social relations and returning to music creation by means of traveling, collecting folk songs and roadshows is a different kind of exploration made by You Come. Referring to the initial intention of creation, Duo Xiaomeng, the chief producer of the program, said that it is difficult for contemporary young people to socialize. Everyone hopes to find like-minded friends, but it is actually not that easy. "So when we are preparing for" You Come ",we hope to conduct a" social experiment "by means of" music+travel "to truly restore the social phenomena in life, so that everyone can have more social possibilities and find their friends more quickly."

"You Come" started broadcasting on April 5th. Photo courtesy of program group

　 　 　 　 Eating has a "meal partner" and fitness has a "fitness partner". Nowadays, the "partner culture" popular on social media is becoming a new social relationship model for young people. "Looking for a music partner" is the key factor in the series. Seven musicians choose their favorite partners through tacit understanding, music commonality and genre preference, and enhance their friendship with songs, and find the best appearance of their friends in running-in again and again. In Duo Xiaomeng’s view, "partner" actually has two meanings. First, it is a new social concept, and then it moves from strangeness to familiarity, and even becomes mutual friends. He believes that a pair of perfect "musical partners" should not only be "similar or complementary in musical style preferences", but also "have the same three views, have emotional intelligence and are sincere".

Diamond. Photo courtesy of program group

In the choice of guest lineup, Duo Xiaomeng has his own set of standards. He believes that "the first thing is to look at the initial relationship of the guests, including acquaintances and strangers. For example, Diamond and Winnie, Ar Fi and Lil Ghost are very good friends in daily life, and they are very topical together. For Ar Fi, except Diamond, he is not familiar with the other five people, so the audience will also see how strangers get acquainted; Secondly, the dimension of personality. Although the personalities of the seven musicians are completely different, they are complementary. For example, Wilber Pan is an E-man, who can quickly blend in with everyone, while martial arts is an extreme I-man; Finally, the music dimension, everyone is stunted, some are good at rap, some are good at lyric songs, some are good at originality, including a variety of music types and expressions. In fact, I hope that everyone can better find their favorite partner. "

"The guests went from strangers they first met to laughing and laughing together, and then went to the back to chat and talk about everything. This process of establishing intimate relationships can give people a strong sense of healing." As Duo Xiaomeng said, "You Come with Sound" is different from other traditional musical ensembles and travel ensembles, and it is more oriented to the core positioning of "socialization". Musicians plan a series of musical performances by means of "taking a partner".

　　CCTV News:The World Health Organization has released the latest edition of the International Classification of Diseases (ICD-11), and one of the most concerned measures is to formally include "Gaming disorder" as a mental illness and bring it into the medical system. It can be seen that with the popularity of smart phones and tablets, game addiction continues to spread and has become a problem in all countries of the world. Solving this problem is also of great significance.

　　Is "addicted to playing games" a disease?

　　Perhaps many people have thought about this issue. Some people want to quit the game, but they can’t extricate themselves, and continue to indulge while scolding themselves; Some parents are worried about their children’s addiction to games and take various measures to send their children to an internet addiction school. Most people think that this is weak willpower and needs restraint. Few people associate "game addiction" with diseases with specific symptoms in physiology and psychology, such as "smoking addiction" and "drug addiction". Now, WHO lists "game addiction" as a formal disease and defines its symptoms:

　　1. Playing video games uncontrollably (frequency, intensity and length of playing video games should be taken into consideration);

　　2, more and more often put video games before other life interests;

　　3, even if there are negative consequences, continue or increase the time of playing video games.

　　In addition, it is worth noting that the World Health Organization is also very strict about the conditions for diagnosing "game addiction". The behavior pattern of the parties must be serious enough, and it has caused great damage to individuals, families, society, education, work or other important aspects, and it usually lasts for at least 12 months before the diagnosis can be made. But it also shows that if the symptoms are serious, the observation period before diagnosis can also be shortened.

　　Who’s definition of "game addiction"

　　With the diagnostic criteria, it means that doctors will treat "game addiction" as a formal diagnosis result in the future, and then prescribe prescriptions and provide treatment plans. More researchers will also collect and analyze relevant data according to this category to promote the emergence of new treatments.

　　At the same time, the World Health Organization also clearly pointed out that only a small number of people who participate in digital or video game activities are affected by game obstacles. However, people who participate in the game should be alert to the time they spend in the game activities, especially when they are too busy to take care of other daily activities, and be alert to any changes in physical and mental health and social functions caused by the game behavior pattern.

　　In China, the Yang Yongxin will make a comeback?

　　Entering "game addiction" into the search engine will lead to a series of shocking social events: Xiao Liuwo, a 17-year-old Guangdong youth, suffered from a cerebral infarction after playing online games for more than 40 hours in the dormitory; A 13-year-old boy from Hangzhou jumped from a building after being reprimanded by his parents for playing "the glory of the king", causing multiple comminuted fractures. When he was taken to the hospital, he was also required to log in to a mobile game account. A 23-year-old woman from Cili, Hunan Province was brutally killed by a 15-year-old junior high school student who was addicted to violent online games and wanted to experience the pleasure of killing people in reality. ……

　　Minors seem to have become the hardest hit areas of game addiction, and the negative effects of these extreme cases have been maliciously amplified. Therefore, the "electroshock therapy" of Yang Yongxin and the "school for abstaining from internet addiction" such as Yuzhang Academy are rampant all over the world, covering up and even praising the abuse of young people such as detention and electrotherapy. Fortunately, such cruel, tyrannical, contrary to modern medicine, and actually rich behavior was finally exposed, and its practice and reputation have been denied among the general public.

　　Then, this time, who lists game addiction as a "disease", will the influence of games on people be demonized again? What needs to be recognized is that "game addiction" and "love to play games" are two concepts, just as drinking addiction is also a mental illness, but this does not mean that there is a problem with drinking itself, and the problem is addiction.

　　In recent years, some schools have set up e-sports majors one after another, and the e-sports industry in China has entered an explosive period, and e-sports has also become an officially certified sport of the International Olympic Committee … There is no contradiction between the public’s acceptance of online games and the classification of game addiction as a "disease". In the meantime, the normative role of the system is particularly obvious. As early as 2005, China issued the first "Online Game Anti-addiction System Standard"; In September 2016, the National Internet Information Office drafted the Regulations on Network Protection for Minors (Draft for Comment); In January 2017, the Legislative Affairs Office of the State Council publicly solicited opinions on the Regulations on the Network Protection of Minors (Draft for Review); In December 2017, Publicity Department of the Communist Party of China and other eight ministries and commissions jointly issued the Opinions on Strictly Regulating the Management of Online Game Market, and the relevant legal systems in China are constantly improving.

　　If it is a disease, it must be cured!

　　In response to this revision, many netizens expressed their support, believing that it will help popularize the concept of Internet addiction and let people face up to their own problems.

　User comments screenshot

　　Some netizens also questioned how it was "sick" when it was good.

　

　　User comments screenshot

　　Although it is controversial that game addiction is classified as "mental illness", in terms of academics, experts have already started research on game addicts. Zhang Jintao, the research group of the State Key Laboratory of Cognitive Neuroscience and Learning of Beijing Normal University, pointed out in the research paper "Brain Mechanism of Abnormal Negative Emotion Processing and Regulation of Online Game Addicts" that a large number of clinical studies and practices have found that online game addicts have a high comorbidity rate with emotional problems such as depression and anxiety. In addition, the lack of ability to adjust negative emotions is also a problem that many online game addicts often report in real life.

　　The experiment shows that online game addicts all show the passive mode of activity in subcortical areas (such as amygdala) and cortical areas (cingulate cortex, lateral prefrontal cortex) when processing negative emotional stimuli and adjusting negative emotions.

　　Screenshot Source: official website, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University

　　This study shows that online game addicts show a similar pattern of neural activity to substance addicts in processing and regulating negative emotional stimuli, suggesting that this phenomenon of neural passivation in processing and regulating negative emotional stimuli is not entirely the effect of taking addictive drugs, but related to addiction itself.

　　In other words, there is no doubt that "game addicts are suffering". It is very important to classify "game addiction" as a disease, so that they can be placed and treated more pertinently and properly.

　　The greatest significance of WHO’s adjustment this time is to remind us to abandon any improper so-called "treatment" means in the past and help people who are addicted to games out of trouble in a more standardized way. This is the progress of our understanding and science. (Text/Dai Mengmeng)