BEIJING, Oct. 15 (Reporter Wu Tao) Recently, it was reported that some users’ mobile phone numbers were "nicknamed" overnight, and they needed to pay extra minimum charges in 39 yuan, just because the last number was "8".

　　There is such an operation? What number is a "good name" and what is the current market situation of "good name"? The reporter conducted an investigation into this.

　　Operator’s latest response to "being nicknamed"

　　Recently, some media reported that Lan Xiaoyue, a user of Guangdong Telecom, used the number for several years and was suddenly "nicknamed".

　　"The staff told me that my number ends with 8 and belongs to ‘ The nickname ’ In addition to paying the monthly primary and secondary card package fee of 199 yuan, the secondary card also needs to pay the minimum consumption in 39 yuan. " Lan Xiaoyue said.

　　As of press time, the reporter of Zhongxin.com has not received a response from China Telecom.

　　In Zhejiang, similar things were reported by the media. Wang Nan, a local mobile user, found that although his "nickname" contract expired in three years, the minimum consumption limit would not end until 2099.

　　However, China Mobile told the reporter of Zhongxin.com that after investigation, none of Zhejiang Mobile’s "nickname" users was called "Wang Nan". "The reporter in the above article can’t provide the customer’s mobile phone number, so it can’t be further verified."

　　The threshold of "nickname" is low, and what is a "nickname" business has the final say.

　　With an "8" at the end, is it a "pretty name"? This reflects a feature of the "beautiful name" market, that is, the threshold of the "beautiful name" market is very low, and it is up to the merchants to decide which numbers are "beautiful names".

　　According to the survey, in addition to the well-known numbers with "888" and "666", some businesses, such as "199****2772", are regarded as "pretty numbers", according to their explanation, because they conform to the rules of the suffix "ABBA".

　　The suffix "178" means "hair together", the suffix "168" means "hair all the way", and the suffix "1349" is a geomantic number, all of which belong to "beautiful names".

　　In short, all kinds of numbers have become interesting in the mouth of merchants, "showing identity, full face and appreciation at guaranteed price" are all sales words of merchants.

　　However, some users said in an interview with Zhongxin.com, "If it weren’t for the explanation of the merchants, I couldn’t see some numbers ‘ Liang ’ Where is it? "

　　Almost all the "pretty names" have set a low monthly minimum consumption. Image source: A screenshot of an operator in official website

　　Want a "pretty name", the price is not small, and you have to spend a lot every month.

　　It doesn’t matter if you can’t see it, it doesn’t affect the popularity of the "beautiful name" market. On the official website of the operator, there are basically no numbers with the tail number format of "AAA" (that is, the tail number is three identical numbers); Don’t even think about the suffix "1314".

　　Moreover, it is not easy to get a "beautiful name", and it is even harder to raise it. Because almost all "beautiful names" have pre-stored phone bills and minimum monthly consumption restrictions.

　　For example, the number "199****3030", even if it is not "beautiful", should be pre-stored in 400 yuan, and the minimum monthly package consumption should be 99 yuan.

　　"It’s not expensive, so the ending number is ‘ AAA’ Yes, the minimum monthly package is 199 yuan. " Some merchants told the reporter of Zhongxin. com.

　　The minimum consumption of such packages basically exceeds the per capita monthly consumption quota announced by operators. Taking China Mobile as an example, its financial report shows that the monthly household income (ARPU) in 2017 was 57.7 yuan.

　　What’s more, if you want a "beautiful number", you not only need to pre-store the phone bill and set the minimum consumption, but also need a "number purchase fee" or a "number selection fee".

　　Different from the basic operators, many communication businesses openly sell "nicknames", and they don’t clearly mark the price, so they have to talk privately one-on-one.

　　Recently, the staff of a communication store on Tmall revealed to the reporter of Zhongxin. com that the price of the card number ending with "AAA" is basically more than 1,000 yuan.

　　Take "177 * * * * 555, China Telecom number and Beijing as an example, the external selling price is 1218 yuan, of which 720 yuan is the prepaid phone bill, which means that the remaining 498 yuan is the" number purchase fee ",and the minimum monthly consumption of this number is 199 yuan.

　　It is illegal for telecom operators to sell "beautiful names"

　　The Measures for the Management of Telecommunication Network Code Number Resources issued by the Ministry of Industry and Information Technology stipulates that after obtaining the right to use the code number, the telecommunication business operator shall not charge the user the selection fee or occupation fee. If there is any violation, the Ministry of Industry and Information Technology may give a warning according to the seriousness of the case and impose a fine of more than 5,000 yuan and less than 30,000 yuan.

　　The above measures also stipulate that the Ministry of Industry and Information Technology can take back the allocated code number resources if it transfers or leases the code number resources or registers the code number as a trademark.

　　Why did this happen?

　　Some operators who did not want to be named told the reporter of Zhongxin. com that at present, it is difficult for consumers to obtain "nicknames" through normal channels and they need to go to the agency market to buy them at a high price; On the other hand, criminals will also hoard numbers and speculate at high prices, resulting in a waste of number resources.

　　"The communication industry does not specify what is ‘ The nickname ’ But some popular or memorable numbers have market value in themselves. "

　　"Operators will not charge users ‘ Selection fee ’ , will be different levels ‘ The nickname ’ Corresponding to different tariff packages for customers to choose from, it is also to make high-quality resources really put on the market to avoid being hoarded and profited by a few people. " The above person said.

　　Fu Liang, an independent analyst in the communications industry, said that operators’ numbers are all applied for by number segments, including "pretty numbers", ordinary numbers and even "difference numbers", but all of them require operators to pay.

　　"Therefore, when reselling the right to use, operators will be interested in ‘ The nickname ’ Make provisions such as prepaid phone bills and monthly minimum consumption restrictions to achieve a balanced income and expenditure. " (End)

recently

Huawei launches the latest flagship smartphone.

Completely detonate the global mobile phone market.

It is worth mentioning that

It is equipped with a domestic 5G chip.

This indicates that China has successfully broken through.

American restrictions and blockades on chips

Have the ability to independently develop high-precision chips.

This is indeed far ahead!

today

Xiaobian wants to show you.

"Far ahead" around us

Installed by China Nengjian Gezhouba Group.

"China Core"-Hydro-generator set

He is a veritable "heart"

runtime

The rotation of that rotor generate a rotating magnetic field.

Cutting stator winding

So as to generate induced potential and output electric energy.

Its installation quality is directly related to.

In the subsequent power generation process

Safety and stability of unit operation

Today, let’s review it together.

"Core" always feels surging power.

Gezhouba hydropower station

Gezhouba Hydropower Station

About

……

Rotor hoisting of Gezhouba Hydropower Station

Gezhouba Hydropower Station is the first large-scale hydropower station on the Yangtze River in China, with a total of 21 large-scale hydro-generator sets, with a total installed capacity of 2.715 million kilowatts. Since the first unit was connected to the grid in July 1981, the rotor of Gezhouba Hydropower Station has been jumping with the sufficient inflow of the Yangtze River for more than 40 years.

Geheyan hydropower station

Geheyan hydroelectric plant

About

……

Rotor hoisting of Geheyan Hydropower Station

Geheyan Hydropower Station has a total installed capacity of 1.212 million kilowatts. The generator rotor of the hydropower station adopts disc support and floating magnetic yoke, and new technologies such as rotor lamination trolley are used in the construction process, and the work efficiency is about three times that of manual lamination.

Three Gorges hydropower station

Three Gorges Dam

About

……

Powerhouse of Three Gorges Hydropower Station

The Three Gorges Hydropower Station is the largest hydropower station in the world. It has designed and installed 32 700,000 kW hydro-generator sets, several of which have been completely localized. In view of the complicated design and manufacturing technology of 700,000 kW domestic water turbine unit, China Nengjian Gezhouba Group successfully solved a series of technical problems such as air gap control of rotor and stator, concentricity and swing control of rotating shaft, and successfully completed the installation of the unit.

Xiluodu hydropower station

Xiluodu Hydropower Station

About

……

Rotor hoisting of Xiluodu Hydropower Station

Xiluodu Hydropower Station is the backbone project of the national "West-to-East Power Transmission". All 18 giant units are designed and manufactured by domestic manufacturers, and the localization scope is constantly expanding. Major castings and forgings and key materials have been localized. In the construction of hydropower station, China Nengjian Gezhouba Group successfully created a construction record of 9 units put into operation for power generation in 11 months. The rotating rotors represent that the commissioning speed and quality of the giant units of China Nengjian Gezhouba Group have reached the world-class level.

wudongde hydropower station

Wudongde hydropower stations

About

……

Wudongde hydropower station factory building

Wudongde hydropower station is the seventh hydropower station in the world and the fourth in China. China Nengjian Gezhouba Group undertook the installation of six 850,000 MW units on the left bank of the hydropower station. The single unit capacity here reached 850,000 kilowatts, which was the largest hydro-generator set in the world at that time. The installation strength of China Nengjian Gezhouba Group is obvious to all.

Baihetan Hydropower Station

Baihetan Hydropower Station

About

……

Hoisting of Runner in Baihetan Hydropower Station

Baihetan Hydropower Station is the largest hydropower project under construction in the world with the highest technical difficulty, with a single unit capacity of one million kilowatts, and is known as the "Mount Everest" in the world hydropower field. In September, 2020, the rotor of the first unit with a capacity of 1 million kilowatts on the right bank, which was built by China Nengjian Gezhouba Group, was successfully transferred into the machine pit, with a weight of 2,300 tons, an external diameter of 16.5 meters and a height of 4 meters, and set a new record in the installation history of large hydro-generator units in the world.

up to this day

China Nengjian Gezhouba Group

Completed successively with high quality and high efficiency.

More than 100 traditional hydropower stations and pumped storage power stations

Installation tasks of more than 350 units

The domestic installed capacity above designated size exceeds 80 million kilowatts.

The installed capacity accounts for a quarter of the total installed capacity of hydropower in China.

Its electromechanical companies are world-renowned.

"the first brand of mechanical and electrical installation"

Original title: "Can’t hide! Far ahead! 》

Read the original text

[Text/Financial Circle Society & Daoge said that cars listen to the wind] Recently, Volvo released its sales data in March. As far as the China market is concerned, Volvo sold 11,608 vehicles in March, down 10% year-on-year. Against the background that Volvo’s global sales increased by 8% that month, it was quite striking. After all, China was the only big area where Volvo declined.

It is worth mentioning that, thanks to the small base in February last year, Volvo’s sales in February increased by 50.4% year-on-year. I thought Volvo’s sales would pick up, but I didn’t expect Volvo’s sales in March to be cold again. As the saying goes, product quality will eventually be reflected in sales volume, and Volvo’s coldness is not without reason.

The editor of "Daoge talks about cars" noticed that some owners of Volvo’s 2023, S90 and S90 new energy models recently complained about the failure of Volvo’s black screen, flower screen and touch screen. You know, these are all 2023 new cars, and it is still difficult to understand that there are car problems.

What is even more frightening is that there are still complaints from car owners about Volvo’s large-scale door paint explosion. What does this mean? Is it Volvo’s indifference, or is there a sudden increase of 2021 -2022 models?

The new car has a car fault and the paint explosion has not been solved yet?

"It’s only one month since the vehicle was purchased. When the vehicle is driving normally, it is listening to music by using the car system. After about 5 minutes, the car screen is black, the music is silent, and the touch screen is invalid." The owner of the 2023 Zhiyi Deluxe Edition complained on the car quality network that the driver needs to be distracted, which greatly affects the normal driving safety and the car experience.

From the feedback of the owner, we can see that the car system failed only one month after the car was bought. I have to say, it is quite shocking. After all, after a long time, the car is stuck and the black screen is still common, but it is rare for a new car to have such problems for a month.

But this is not an isolated case. A 2023 Zhiyi Deluxe Edition (plug-in) owner said in a complaint that since the car was upgraded to version 2.5 on December 18, the carplay function has been frequently unavailable, and the display function has been spent every day without exception. According to the owner, after the 4S shop was upgraded, the problem remained.

It is understood that both the 2023 Volvo XC60 and the 2023 Volvo S90 were listed in July and June last year respectively, that is to say, in the case of less than one year’s use, the above-mentioned car owners had car trouble during the use of the vehicle. In fact, several years ago, Volvo products had car trouble, but I didn’t expect that even new cars could not escape.

However, compared with these, the problem of paint explosion on the doors of Volvo’s models may be even more frightening. As early as last December, Daoge said the car had reported the problem of paint explosion on the doors of Volvo’s models, but judging from the complaints about Volvo models in the car quality network, the complaints about paint explosion on Volvo doors have never stopped from beginning to end.

From the feedback of complaints, the phenomena of paint blistering and bulging mostly appear on the inside of vehicle doors, and the models involved cover high-standard models such as XC40, XC60 and S90, and most of them are 2021 models and 2022 models. "Asia-Pacific Volvo XC60, the paint on the inner side of the door frame blistered and continued to expand. The manufacturer did not give the cause of the problem, did not have a thorough maintenance plan, and needed lifelong maintenance, and asked the manufacturer to give a statement and compensation for the depreciation of the vehicle. "A 2021 Volvo XC60 Zhiyuan Deluxe Edition owner said in a complaint.

In fact, there are many reasons for car paint foaming, including poor paint quality, poor construction conditions, imprecise technology and internal rust. This kind of problem rarely appears in luxury brands. After all, the average price of Volvo is very high, and even the price of S90 cars is more than 400,000 yuan. Will cars at this price not be able to paint? I have to say that Volvo’s performance has somewhat lost the face of luxury brands.

It is worth mentioning that, judging from the recent feedback complaints, more and more car owners are not only reflecting the problem, but are mixed with the willingness to let Volvo give a statement. A car owner of the 2021 Volvo XC60 Zhiyuan Deluxe Edition put forward in the complaint that he strongly urged the manufacturers to issue an announcement to explain the specific reasons for the foaming at the door of a large number of vehicles, and strongly urged the manufacturers to issue a specific maintenance plan for the foaming at the door and ensure a one-time repair …

It’s time for Volvo to reflect on warmer sales and colder sales.

It is often said that product quality will ultimately be reflected in sales volume, which may be equally applicable to Volvo. In February this year, Volvo sold a total of 13,016 vehicles in China, a year-on-year increase of 50.4%. Thanks to this, Volvo’s sales in the first quarter also increased by 2% year-on-year to 36,457 vehicles.

Volvo’s sales have picked up, haven’t they? But most of them are "illusions". As we all know, the month in which the Spring Festival in China is held every year is a downturn in the automobile market. The reason is that no one sells cars during the Spring Festival holiday, and so is Volvo. Last year’s low base allowed Volvo to get a good-looking data in February, which in turn made Volvo’s data in January look good.

However, if we only look at the sales volume in March, Volvo’s sales volume is cold. Volvo’s sales volume in China in March was 11,608, down 10% year-on-year, which is the only decline among Volvo’s global regions including Europe and the United States. Obviously, Volvo’s sales have not actually "recovered".

As for the reason, the new car mentioned above has engine failure, and the door paint explosion problem in a large area of its models may also be one of them. It is worth mentioning that in fact, there is another reason behind the problem of car door paint explosion, that is, Volvo’s indifference. Take XC60, which has a serious car door paint explosion problem, as an example. The complaint interface of Chezhi.com shows that in 2023, Volvo’s complaint response rate is 0.8%.

What concept? Probably Volvo has never paid much attention to these car owners who complained, and the response rate of those self-owned brands ranked first in some complaint websites is basically close to 100%. Why Volvo is so noble, we don’t understand it very well, but this way of handling also makes the owners of XC60 very dissatisfied, and the satisfaction of the owners is only 1.2 points. Judging from the monthly sales of Volvo in the past three years, it has never exceeded 20,000 vehicles. Now, it seems that it is not necessarily that China people don’t understand cars!

Immunotherapy has become a trump card in the fight against cancer! By stimulating the ability of our immune system to fight cancer, it sets up a brand-new principle for cancer therapy, which can be said to be a milestone in the process of human struggle against cancer!

In addition to the well-known immune checkpoint inhibitors, CAR-T therapy is undoubtedly the leader in the field of global cancer cell immunotherapy. Because of the successful research and development of CAR -T therapy, it has created a miracle of "curing" cancer. This treatment method has been proved to induce significant reactions-even patients with advanced cancer whose survival time is only a few months can be completely eradicated, and in some cases the strong response lasts for months or even years. For example, Emily, a leukemia girl, was dying after being diagnosed at the age of 5, but now she has been successfully cured by CAR-T cell therapy for nearly 10 years, and she has become the spokesperson of this epic therapy and has been recorded in history.

Emily, a leukemia girl, declared cancer-free for 9 years.

CAR-T therapy brings changes to global cancer treatment.

In recent years, there has been a worldwide upsurge in the research and development of CAR-T therapy, because whoever makes CAR-T therapy technology with better curative effect and lower side effects will undoubtedly take the lead in eating the first crab and open a new era of tumor immunotherapy. At present, six CAR-T therapies have been approved by FDA, and two CAR-T products have been listed in China, and seven CAR-T therapies have been approved worldwide!

Unfortunately, CAR-T therapy is only approved in hematological tumors at present, because the tumor cells of hematological tumors have ancestral targets, such as CD19 (only existing in tumor cells but not in normal cells), and we can easily rely on this target to lead CAR-T cells to find cancer cells and eliminate cancer.

However, there is no such obvious target in solid tumor that exists only in cancer cells but not in normal cells. Therefore, the clinical efficacy of CAR-T cells in the treatment of solid tumors has been poor. The medical community has always hoped that CAR T cells can develop new specific targets for more solid tumors!

The rise of new anti-cancer forces! Six solid tumor CAR-T therapies bring unprecedented survival breakthrough!

At present, with the change of CAR-T algebra, CAR-T has obviously improved in proliferation and cytokine release, and this technology has finally broken the ice. More and more clinical trials have begun to try to use CAR-T in the treatment of solid tumors, and patients with advanced solid tumors are welcoming warm spring!

Representative antigen targets include:

Mesothelin for the treatment of mesothelioma, pancreatic cancer, ovarian cancer and lung cancer;

CEA is used to treat lung cancer, colon cancer, gastric cancer, breast cancer and pancreatic cancer;

MUC-1 is used for treating liver cancer, lung cancer, pancreatic cancer, colon cancer and gastric cancer;

GPC3 for the treatment of liver cancer;

EGFＲvII is used to treat glioma and head and neck tumors;

B7-H3, used for treating Ewing sarcoma, rhabdomyosarcoma, nephroblastoma, neuroblastoma and medulloblastoma, as well as brain stem tumor (DIPG) which is particularly difficult to treat;

PSMA, used for prostate cancer, etc.

Claudin18.2, used for gastric cancer, pancreatic cancer, etc.

….

Application of 01GPC3 CAR-T in liver cancer

Liver cancer is the second leading cause of cancer death in the world (accounting for 8.2% of the total). Although great progress has been made in diagnosis and treatment in recent years, the effect of current targeted and immunotherapy is limited, and better treatment schemes are urgently needed in clinic.

GPC3 is a carcinoembryonic antigen, which is involved in cell proliferation, differentiation, migration and apoptosis. What excites researchers is that GPC3 protein is almost not expressed in 21 normal tissues such as heart, liver, spleen, lung and kidney, but it is expressed in 70-80% hepatocellular carcinoma and lung squamous cell carcinoma. GPC3 is considered as a promising tumor immunotherapy target because of its tumor specificity. The good news is that there are monoclonal antibodies, double antibodies, therapeutic vaccines and GPC3 CAR-T therapy for this target, which have shown great potential in liver cancer.

In 2020, good news came from the Chinese team: the results of Phase I clinical research on the treatment of advanced hepatocellular carcinoma (HCC) with the second generation CAR-T cell therapy targeting GPC3 were released, and the research results were published in the international heavy oncology journal Clinical Cancer Research, which caused a sensation. It is worth mentioning that this is the world’s first clinical trial targeting GPC3 CAR T cells to treat hepatocellular carcinoma, and the research results of Chinese scientists once again shine on the world stage.

In this newly published study, 13 patients with advanced liver cancer were enrolled (from December 2015 to July 24, 2019).

The results show that:

Of the 13 subjects, 2 obtained partial remission (PR);

The 3-year, 1-year and 6-month survival rates were 10.5%, 42.0% and 50.3% respectively.

The median survival time (OS) was 278 days (95% CI: 48,615 days).

Two patients with advanced liver cancer, numbered 3 and 13, were very lucky. After receiving GPC3 CAR T treatment, the lesions were significantly reduced, and some of the target lesions even subsided!

The good news is that the new T-therapy has officially started to recruit patients in China. At present, several well-known cancer hospitals in China have taken the lead in clinical research, and some patients have successfully entered the group through the application of the global oncologist network.

In addition, at the virtual annual meeting of the American Society of Clinical Oncology (ASCO) in 2021, CARsgen Therapeutics presented a new fourth-generation chimeric antigen receptor T (CAR-T) cell ORI-CAR-001 (NCT03980288) based on the second-generation CAR-T.

The fourth generation of CAR-T cells can secrete transgenic cytokines when targeting CAR signal transduction in tumor tissues after additional engineering modification. Therefore, in addition to direct anti-tumor attacks, they can also trigger T cells to eliminate antigen-negative cancer cells in the target site, which is more effective!

The preliminary results of this study show that the safety and effectiveness of Ori-CAR-001 in patients with GPC3 positive recurrent/refractory HCC are encouraging.

By March 10th, 2021, 11 patients had participated in this study. All subjects were advanced hepatocellular carcinoma, and previous treatment methods (including chemotherapy, TACE and targeted therapy) failed.

The results showed that among 9 evaluable subjects, 4 achieved partial remission (PR), 3 achieved disease stability (SD) and 2 developed disease progression (PD). The objective remission rate was 44.4%, and the disease control rate reached 77.8%.

It is worth mentioning that the tumor volume of subject 007 decreased by more than 80% one month after cell therapy infusion! Subject 012 also saw a good tumor response. He had advanced and diffuse large HCC and joined the study after radiotherapy, targeted drugs and 12 TACE failures. On the 28th day after CAR-T cell infusion, the diameter of the target tumor lesion decreased from 133 mm at baseline to 9 mm, a decrease of more than 93%. At present, the subject is being evaluated at the third month after CAR-T cell infusion, and MRI scan shows that the tumor has almost completely subsided!

02

Application of claudin18.2 CAR-T in gastric cancer and pancreatic cancer

Claudin 18.2 is a target of pantumor, which is expressed in many epithelial tumors, especially in gastric cancer and pancreatic cancer. In gastric cancer or gastroesophageal junction cancer, the high expression of Claudin 18.2 was detected in as many as 60% patients. Based on this, researchers in China developed the first CAR-T cell therapy for Claudin18.2 –CT041.

The preclinical research results of CT041 cells in the treatment of gastric cancer show that gastric tumors can be completely eliminated in mouse models without off-target toxicity.

Based on excellent preclinical data, China took the lead in developing a multi-center, open-label phase I clinical study of Claudin 18.2 CAR-T cells in the treatment of patients with digestive system tumors, including dose escalation stage and dose expansion stage. The main purpose was to evaluate the safety and tolerance of CT041, and the secondary purpose was to evaluate the efficacy and pharmacokinetics.

It is worth mentioning that all the patients in the group have received second-to third-line treatment, Claudin 18.2 is moderately highly expressed, most of them have multiple organ metastases, and nearly half (42.9%) of them have also received PD-1 treatment, which is extremely difficult to treat clinically.

Experimental design:

By April 8, 2021, 37 patients had received CT041 infusion and completed the evaluation for at least 12 weeks, including 28 cases of gastric cancer/gastroesophageal junction cancer (GC/GEJ), 5 cases of pancreatic cancer (PC) and 4 cases of other digestive system tumors. The dose levels of CAR-T cells were 2.5× 10, 3.75× 10 and 5.0× 10, respectively.

The results show that:

The target lesions of 31 patients were reduced in different degrees. The overall objective remission rate (ORR) was as high as 48.6%, and the disease control rate (DCR) was 73.0%.

Source CARsgen Therapeutics

Among them, the objective remission rate (ORR) and disease control rate (DCR) were as high as 61.1% and 83.3%, respectively, in 18 patients with gastric/gastroesophageal junction cancer who failed in at least second-line therapy (including 8 patients who had received PD-1) at the dose of 2.5× 10 CAR-T cells. MPFS is 5.6 months and mOS is 9.5 months.

Source CARsgen Therapeutics

In terms of safety, CT041 is generally well tolerated. No treatment-related deaths or immune cell therapy-related neurotoxic syndromes (ICANS) were reported. About 95% patients experienced CRS, all of which were Grade 1 or Grade 2.

The reason why domestic experts agree that this data is excellent is because historical data show that the effective rate of chemotherapy is only 4% ~ 8% and the effective rate of anti-PD-1 antibody is only 11% for patients with gastric/gastroesophageal junction cancer who failed at least the second-line treatment in the past, and the objective remission rate of CT041 for second-line treatment failure, even after PD-1 treatment failure, can be as high as 61.1% (which means 61.1% in the late stage)

In addition to the above data, the treatment of two patients who achieved objective remission was also announced:

01

Patient 04, 53-year-old male.

Source CARsgen Therapeutics

Advanced gastric cancer with liver, lung, bone metastasis and multiple lymph node and peritoneal metastasis has received two kinds of systemic therapy, including PD-1 antibody, CLDN was 18.260% (3+). After CAR-T therapy, the tumor shrank by nearly 50% and remained in remission for 32 weeks.

02

Patient 08, 57-year-old female.

Source CARsgen Therapeutics

GC has peritoneal metastasis and Mary Joseph’s nodule (a nodular lesion formed by the metastasis of malignant tumor to the umbilical region). It has received 3-line therapy including PD-1 antibody and CLDN18.2 80%(2+) before, and achieved partial remission after CAR-T treatment, and continued to respond for more than 56 weeks.

03

Application of gucy2car-t in colorectal cancer

C(guanylyl cyclase C (GCC/GUCY2C) is a member of the receptor guanyl cyclase family, and it is the receptor of guanyl, guanyl and Escherichia coli enterotoxin, and plays a key role in the liquid and ion homeostasis of gastrointestinal tract. About 80% patients with colorectal cancer have positive expression of GCC. The expression of GCC in normal tissues is limited to the top of intestinal epithelial cells, but not in other tissues and organs. In recent years, it has been found that GCC is stably expressed in primary colorectal cancer cells, but abnormally highly expressed in metastatic colorectal cancer cells, which is considered as one of the specific marker molecules of metastatic colorectal cancer.

GCC19CART is an autologous CAR-T therapeutic product, which is the leading solid tumor therapy for the treatment of relapsed and refractory metastatic colorectal cancer (R/R mCRC). GCC19CART specifically targets and eliminates cancer cells that express colorectal cancer tumor marker GCC. According to public information, the clinical trial of 35 patients with relapsed and refractory colorectal cancer conducted by GCC19CART in China has achieved initial results. In the early clinical trial (IRB) initiated by China, the researchers enrolled 35 patients with advanced colorectal cancer. Among the 8 patients who received a dose of 2×106 GCC19CART cell/kg in the dose climbing test, an objective remission rate of 50% was observed.

On April 19th, 2022, Shanghai Stensai Bio announced that its solid tumor CAR-T product GCC19CART was granted fast-track qualification by the US Food and Drug Administration (FDA). Have to say, this honor makes China CAR-T therapy take another solid step on the road of overcoming solid tumor, which is worth looking forward to!

04

Mesothelin CAR-T therapy

Mesothelin is a cell surface glycoprotein, which is highly expressed in many tumors, such as malignant pleural mesothelioma, pancreatic cancer, ovarian cancer and part of lung cancer, but poorly expressed in normal pleura, peritoneum and pericardium. Preclinical studies show that CAR-T cells targeting mesothelin have potential anti-tumor effects.

The latest results of mesothelin CAR-T therapy published by the University of Pennsylvania at the American Society of Clinical Oncology in 2019 showed that six patients with refractory metastatic pancreatic ductal adenocarcinoma were successfully enrolled, and all patients had received two or more treatments. These patients were infused with mesothelin CAR T cells three times a week for a total of nine doses. The results showed that there were 2 patients with stable diseases, and their progression-free survival time was 3.8 months and 5.4 months.

Therefore, this new therapy has biological activity in patients with pancreatic cancer, and this study is still in clinical trials (NCT03323944). At present, a large number of mesothelin CAR-T clinical studies have been carried out in China, and preliminary results have been achieved. In mouse experiments, the tumors of advanced ovarian cancer mice receiving the new mesothelin CAR-T therapy have rapidly subsided. At present, this technology is recruiting all kinds of patients with advanced solid tumors in China. Those who want to participate can apply to the Medical Department of the Global Oncologist Network.

Spring is blooming, and more new treatments are on the way!

Before the advent of cell therapy, solid tumors, including advanced gastric adenocarcinoma and pancreatic cancer, were usually treated by surgery, radiotherapy and chemotherapy. Among them, the incidence of gastric adenocarcinoma accounted for 95% of gastric malignant tumors, and pancreatic cancer was the most malignant tumor among common tumors. The median survival rate and 5-year survival rate were far lower than other tumors, so it was called "the king of cancer". However, most patients will have local recurrence or metastasis after operation. In addition, this kind of malignant tumor is not sensitive to radiotherapy and chemotherapy. Therefore, based on the current standard therapy, the treatment effect is not ideal, and the prognosis is extremely poor. The emergence of immunotherapy will bring hope and miracle for long-term survival to more advanced patients.

We firmly believe that after the introduction of a perfect cellular immune regulatory system, the country will open the door of cellular immunotherapy to benefit more cancer patients, and our country’s cellular immunotherapy will also enter the international stage!

　　On May 30th, local time, British telecom operator EE and Huawei officially opened the first commercial 5G signal in the UK.

　　It is understood that this 5G commercial release covers six major cities in the UK, and about 450,000 EE users have registered applications for upgrading 5G. EE’s business hall in London had a long queue on the morning of the 30 th and could not wait to experience the 5 G network. According to the released test data, even in the busiest areas, users can experience the network speed of 100~150Mbps, which is achieved when EE only has the C-Band 40MHz spectrum.

　　After about 450,000 EE users registered to upgrade the 5G network, the British Broadcasting Corporation (BBC) conducted a live news broadcast based on the 5G network. Rory Cellan-Jones, a well-known BBC technical reporter, used a 5G terminal to broadcast the historical moment when Britain entered the 5G era. This is also the first live TV broadcast based on commercial 5G network in the UK.

　　It is understood that this commercial release of EE has eliminated concerns that Huawei’s blockade by the United States may delay the arrival of 5G in Europe. Marc Allera, CEO of EE, said: "There is a lot of news about security at present. Our 5G release is provided by multiple suppliers, and Huawei is an indispensable part."

　　It is understood that EE, together with other British operators, continues to use Huawei equipment in its wireless access network.

　　With regard to the commercial launch of 5G in the UK, Ben Wood, an analyst with CCS Insight, said: "Many critics believe that Europe is lagging behind in 5G, but it is more important to realize that the first commercial launch of 5G, including EE, will come before the launch in China and Japan and will not lag behind South Korea. From now on, 5G will advance at full speed in the UK. "

　　EE will build a network at the rate of more than hundreds of 5G sites every month, and complete the deployment of 1500 5G sites in 2019, adding 5G coverage in 10 cities. It is understood that EE’s 5G network is mainly deployed by Huawei’s Massive MIMO equipment. Huawei’s 5G Massive MIMO is currently ahead of the industry in terms of performance and engineering capabilities, and there is no alternative competitive product. At the same time, for indoor scenes such as football fields and shopping malls, EE will also use Huawei’s 5G indoor digital system (DIS).

　　In addition to EE, Vodafone, another British operator, will also launch 5G services within five weeks. According to a Vodafone spokesperson, the construction of Vodafone’s 5G network also uses Huawei’s 5G equipment.

　　The Paper reporter Ling Zhou

According to the news of the preferential promotion channel in Shihezi, car home, at present, the models are being promoted at a reduced price in Shihezi. It is understood that this model can enjoy a maximum discount of 15,000 yuan, and the minimum starting price is 122,200 yuan. If you are interested in Xingyue L model, you can click "Check the car price" in the quotation form to get a higher discount.

Xingyue L is an SUV with a modern and dynamic design. Its front face design adopts a unique "flapping" design concept, and the air intake grille is decorated with a large area of chrome, showing a sense of luxury and movement. The body lines are smooth and the overall style is fashionable, giving people a strong visual impact. In addition, the Xingyue L car series is also equipped with high-tech configurations such as LED headlights, LED daytime running lights and LED taillights, which not only improves the lighting effect of the whole vehicle, but also increases the recognition and fashion sense of the vehicle. At the same time, the chrome trim strips on the side of the car body and the shape of the rim also add a sense of exquisiteness to the whole car. Generally speaking, the design of Xingyue L car has both a sense of technology and luxury, and it is an SUV model favored by consumers.

As a medium-sized SUV, Xingyue L has a body size of 4770*1895*1689, with a wheelbase of 2845mm and a front and rear track of 1610 mm. The side lines of the car body are smooth and have a strong sense of lines. The rims are made of 235/50 R19 tires, which increases the sense of movement of the car. In addition, the tyre size of Xingyue L is consistent, which is 235/50 R19, and the overall collocation is very harmonious. The exquisite design of the side lines and the rim style make the car more fashionable and dynamic, and bring more comfortable driving experience to consumers.

The interior design of Xingyue L is fashionable and simple. The center console adopts a 12.3-inch large screen and is equipped with voice recognition control systems such as multimedia system, navigation, telephone, air conditioner and skylight, which is convenient for drivers to operate. The steering wheel is made of leather material, which can be manually adjusted up and down and back and forth, so that drivers can find the most comfortable driving posture. The front and rear rows are equipped with USB and Type-C interfaces, which are convenient for connecting mobile phones and other devices. The seat is made of imitation leather. The main driver’s seat supports fore-and-aft adjustment, backrest adjustment, height adjustment (2-way) and lumbar support (4-way), and the co-pilot’s seat also supports fore-and-aft adjustment and backrest adjustment. The front seats are also equipped with heating and ventilation functions (driver’s seat only), and the electric seat memory function supports driver’s seat adjustment. The rear seats can be laid down in proportion, which increases the space utilization in the car. Generally speaking, the interior design of Xingyue L pays attention to comfort and practicality, which provides a good driving experience for drivers and passengers.

Xingyue L is equipped with a 2.0T L4 engine with a maximum power of 160 kW and a maximum torque of 325 N m.. This engine adopts wet dual-clutch gearbox, which can shift gears smoothly and quickly. At the same time, the engine’s efficient combustion and low emission design allow drivers to enjoy strong power while maintaining environmental awareness.

In the evaluation of the owner of car home, he spoke highly of the appearance of the Star Yue L, thinking that its appearance is atmospheric, like Volvo. He even said that if you don’t look at the brand, you can consider buying this car. This means that the star Yue L has done a very good job in design, which not only meets the aesthetic needs of consumers for atmosphere and luxury, but also shows its unique brand style. Therefore, if you are looking for an atmospheric and luxurious SUV, Xingyue L is undoubtedly a very worthy choice.

On April 22, 2010, in the New China Exhibition, some exhibition cars from auto china entered the museum.

　　　　 The 11th beijing international automotive exhibition 2010 will be held in the new China International Exhibition Center (Tianzhu) and the old China International Exhibition Center (Jing ‘anzhuang) from April 25th to May 2nd, 2010.

　　　　 The new national exhibition mainly displays domestic and foreign passenger cars and commercial vehicles. The exhibition date of the old national exhibition is April 23-April 27, which mainly displays domestic and foreign auto parts and related products. This year’s auto show has more than 2,100 exhibitors from 16 countries and regions, with an exhibition area of nearly 200,000 square meters.

The schedule of this auto show:

1. The new China International Exhibition Center.

April 23 and April 24The exhibition news day is dedicated to receiving visits and interviews from domestic and foreign media reporters. The press day only accepts media personnel and exhibitors with exhibition press cards. Daily exhibition time: 9: 00-18: 00.

April 25th and 26th., professional visit day, daily exhibition time: 9: 00-17: 00

27 April-2 May, public visit day, exhibition time: 9: 00-17: 00, of which, the exhibition time on May 1st is 9: 00-18: 00. Exhibition time on May 2nd: 9: 00-15: 00,

2. Old China International Exhibition Center.

23 April-27 April 2010Exhibition time: 9: 00-17: 00.

The visit time is from 9: 00 to 15: 00 on April 27th. Professional visitors are admitted free of charge after registration.

3. Schedule of main activities:

On April 24th, from 12: 00 to 17: 00, a public welfare activity will be held in the new National Exhibition Hall.

At 10: 00 am on April 25th, the opening ceremony of this auto show was held in the South Landing Hall of the new National Exhibition Hall.

　　On December 28th, it was 1003 days since Xiaomi officially announced the car, and less than 100 days after the first car SU7 was officially released.Finally held the first press conference in Beijing. In two and a half hours, Xiaomi Chairman and CEO Lei Jun was right., platform architecture, self-developed CTB integration, die casting, automatic driving, intelligent cockpit and other technologies, as well as the design of the first car SU7.

　　It is worth mentioning that there have been rumors in the industry that the starting price of the first car is 149,000 yuan. When explaining the products, Lei Jun said that the price of products with the same performance and configuration is more than 400,000 yuan. "Don’t talk about 99,000, it’s impossible, and don’t talk about 149,000. We still have to respect technology."

　　Just a few days before the press conference, Lei Jun himself frequently voiced through the media and social platforms to explain the concept and goals of Xiaomi Automobile. Xiaomi Auto even included several outdoor billboards,、, Ideal, Huawei, etc.The car "pioneer" pays tribute. However, Lei Jun did not disclose the information about the price of products that users and industries are more concerned about.

　　In March 2021, Xiaomi officially announced its entry into the smart electric vehicle industry, and plans to achieve mass production in the first half of 2024. In Q1 financial report in 2021, Xiaomi put forward the strategy of intelligent electric vehicle for the first time.

　　In September 2021, Xiaomi officially registered Xiaomi Automobile Co., Ltd. with a registered capital of 10 billion yuan, and Lei Jun personally served as the legal representative.

　　At the same time, Xiaomi officialThe photo of Lei Jun and the other 16 team backbones was released. Except for Li Tianyuan, a former BMW Group IX designer, the others were all internal backbones of Xiaomi. Lei Jun personally took the lead as CEO of Xiaomi Automobile, and three Xiaomi partners, Hong Feng, Lu Weibing and Liu De, served as Xiaomi Automobile.And supervisors.

　　Since then, Xiaomi has rapidly recruited mature talents in the automotive industry in the fields of R&D, manufacturing, supply chain and intelligence, including Yu Liguo, former president of Polar Fox, Huang Zhenyu, former vice president of Magna China, and Hu Zhengnan, former president of Geely Research Institute.

　　The reporter learned that compared with traditional car companies, the organizational structure of Xiaomi Automobile is flatter. More than 10 business divisions have been established under CEO Lei Jun, and the general manager of each business division reports directly to Lei Jun.. Among them, Huang Zhenyu from Magna is the general manager of the supply chain department, and Li Xiaoshuang from Xiaomi’s former department is the general manager of the marketing department.

　　The construction of Xiaomi Auto Autopilot Team was earlier than the official registration of the company. In July 2021, Xiaomi released 500 jobs related to autonomous driving on the official recruitment interface, including decision-making planning, algorithms and other fields of autonomous driving. In August 2021, Xiaomi announced the acquisition of Shendong Technology, an autonomous driving technology company, with a total transaction amount of about 77.37 million US dollars. Since then, the former CEO of Shendong Technology Cai Rui, CTO Li Zhiwei, chief scientist Yang Kuiyuan and R&D director Zhang Chi have joined Xiaomi Automobile. In Xiaomi’s official micro-business, the above four people are called "super brain" of Xiaomi Automobile.

　　As of the second quarter of 2023, the number of R&D personnel related to Xiaomi Automobile has approached 3,000. Recently, Lei Jun said in an interview with the media that Xiaomi’s first car invested 3,400 engineers as a whole, and the entire R&D investment exceeded 10 billion.

　　Different from Huawei’s smart car selection model and new OEM model, Xiaomi Automobile decided to firmly grasp manufacturing in its hands. In the second quarter of 2022, the construction of Xiaomi Automobile’s car-making base in Yizhuang New City started. CBN previously reported that Xiaomi Automobile Factory will be built in two phases. The first phase covers an area of nearly 720,000 square meters. It will be started in April 2022 and completed in June 2023. The annual production capacity is expected to reach 200,000 vehicles. The whole base includes six workshops, including die casting, stamping, body painting, final assembly and so on, which are divided into No.1 workshop for punching, welding, painting and power to No.4 workshop and test building. The second phase is planned to start in 2024 and be completed in 2025.

　　On December 25 and 26 this year, Lei Jun published "small essays" on Xiaomi Automobile in succession, and published his views of "insisting on positive development and starting from the underlying core technology". At today’s press conference, Lei Jun said that in the first stage of the automobile industry, cars were just travel vehicles; In the second stage of the automobile industry, the automobile is transformed into a mobile computing terminal; In the third stage of the automobile industry, the automobile will further evolve into an "advanced mobile intelligent space", and this is the starting point for Xiaomi to build a car.

　　In order to ensure the success of the first car, Lei Jun called it "ten times investment to build a good car", with a total R&D investment of 10 billion yuan. At today’s press conference, Lei Jun introduced Xiaomi’s investment and achievements in the fields of electronic control, die casting integration and self-developed battery technology. Among them, Xiaomi has applied for 155 patents in the field of electronic control and obtained more than 60 patents.

　　In the core field of automatic driving and intelligent cockpit, Xiaomi Intelligent Driving System has the functions of calling vehicles with one button, automatically entering the ramp, actively changing lanes and overtaking, unprotected turning/turning, automatic parking service and so on, covering high-speed, urban areas, parking lots and other scenes. In addition, Xiaomi’s self-developed 澎湃 OS also announced to get on the bus, realizing the complete opening of the whole ecology of people and cars.

　　The opening of Xiaomi automobile, Xiaomi mobile phone and Xiaomi ecological products is also considered to be the biggest advantage of Xiaomi car.

　　The revolution of intelligent electric vehicle is not only the upgrade of automobile power form, but also the key change lies in the establishment of electronic and electrical architecture, the decoupling of software and hardware technology and the development of intelligent application. Automobile has derived hardware and software control systems from mechanical parts, and applications such as assisted driving and intelligent cockpit have intensified the industrial differentiation of smart cars, and formed a series of industrial chain links such as mechanical parts, hardware, software, internet and charging.

　　As a leading manufacturer of smart phones, Xiaomi has a deep accumulation in the field of software algorithms. Chips, cameras and panels are also important parts of automobiles. Xiaomi Automobile can improve R&D efficiency and quality by reusing R&D talents and supply chains of mobile phones and other businesses.

　　In addition, "mobile phone ×AIOT () "is the core strategy that Xiaomi has adhered to for a long time. By Q2 of 2023, the connected equipment of Xiaomi AIOT platform has reached 655 million; The number of active users of Mijia APP reached 82.9 million. The addition of smart cars will make Xiaomi’s layout in the intelligent hardware ecosystem more perfect and have greater value. In the future, Xiaomi will realize mobile phones, cars, tablets, wearable devices,Fully connected, fully integrated in operating system, application ecology, underlying data and hardware mutual assistance, creating a new experience of multi-device collaborative cross-device and cross-scene intelligent cockpit.

　　It is believed that the car system and native application of Xiaomi Automobile will also become favorable channels for Internet advertising. mounted on a vehicle, audio-visual entertainment, etc. may also build a sharing mechanism similar to mobile phones, which is expected to become an additional channel for realizing the company’s Internet business. At the same time, considering the high-end positioning of Xiaomi smart car, the ARPU space of advertising and other services is expected to be higher than the average level of mobile Internet services. Due to the nature of high gross profit,It is the core business of Xiaomi to create profits, and this logic is also expected to be fulfilled on the automobile side.

　　The reporter noticed that as a company good at software and a "new army" in the automobile industry, Xiaomi Automobile’s research and investment in automobile technology and materials broke the outside world’s perception of Xiaomi. At the technical conference, Xiaomi Automobile released the super motor V8s, which has a rotating speed of 27200rpm, a maximum horsepower of 578ps, a peak power of 425kW, a peak torque of 635N.m, a maximum efficiency of 98.11% and a power density of 10.14kW/kg. It is expected to get on the train in 2025. At present, the mainstream motor speed in the industry is below 20000rpm, onlyThe motor speed of a few products such as, Zhiji can exceed 20000rpm. Lei Jun also said at the press conference that the power density of Xiaomi automobile motor is ahead of that of Porsche.

　　At the same time, the Xiaomi super motor technology is pre-researched, and the carbon fiber laser winding process is adopted, and the rotation speed reaches 35000rpm；; In terms of car body, Xiaomi Automobile adopts the self-developed material "Xiaomi Titan Alloy", which contains 30% recycled aluminum, and Xiaomi Automobile has become the second car company to independently develop car body metal materials; In addition, Xiaomi’s first product, SU7, will also adopt technologies such as battery body integration (CTC) and integrated die casting.

　　As the time for mass production to market approaches, information about suppliers of SU7, Xiaomi’s first pure electric car, has surfaced one after another, among which battery cells come from.And its subsidiary Xiangyang Fudi Co., Ltd., will provide three yuan respectively.And iron phosphate; ABS braking system comes from Bosch Suzhou; The driving motors are provided by Suzhou Huichuan United Power System Co., Ltd. and United Automotive Electronics Co., Ltd. respectively. Besides,、、、、、、、、、A number of A-share listed companies have said that they have entered the Xiaomi Automobile Purchasing Group.

　　In addition, Xiaomi has invested in a number of electrification and intelligent parts., three electric systems, intelligent cockpit and intelligent driving companies, including more than 30 investments in the field. In the field of intelligent driving, Xiaomi acquired Shendong Technology and invested.Technology,wait for、Millimeter wave radar company has basically realized the layout of the whole industrial chain of intelligent driving.

　　Some analysts in the industry believe that smart electric vehicles are in the most competitive knockout stage, and Xiaomi cars are too late to catch up with the most "rolling" stage. But there are alsocompanyIt is believed that the smart electric vehicle is going through the transition stage from the initial stage of smart phone development to the second half, and the market concentration is still relatively low. From the structure of the development history of the mobile phone market, the first Mover may not come to the end, and the latecomers still have the opportunity to catch up.

Dark Phoenix crew

The annual new york International Animation Expo opened recently in Javits Convention and Exhibition Center, new york. Two new heavyweight films, X-Men: Dark Phoenix and Alita: Battle Angel, made their debut in the comic exhibition. The film’s creators shared interesting stories with fans during the film making process, and even showed wonderful clips of the films that had never been disclosed before. Bad Times at the El Royale, a thriller and suspense masterpiece that will be fully released on October 12th, also held a film meeting at the comic exhibition, which was well received by movie-watching fans. Previously, foreign media had a very good evaluation of the film.

Sophie revealed that the director of "Microwave Rehearsal Method" praised "Model Worker Sister" for paying attention to details.

As the latest sequel to the classic IP "X-Men", "X-Men: Dark Phoenix" brings the plot line that is popular among fans to the big screen, and the lineup of Cass is Starlight Glimmer, which brings together many new and old movie stars. The "Iron Triangle" composed of Jennifer Lawrence, Michael Fassbender and James McAvoy continues to play the leading role, while a large number of beloved powerful stars such as Sophie Turner, Tye Sheridan and Jessica Chastain are newly joined.

Simon Kinberg, the director, and Simon Kinberg, the producer, and sophie turner and Tye Sheridan, the two leading actors, appeared at the booth to share the original intention and anecdotes of the film. Sophie, who is familiar with the role of "Sansa" in Quan You, has made great efforts to play Jean Grey. In order to feel the feeling of being permeated by cosmic energy, she often stands by the microwave oven to "absorb energy" and even yells at her mother. Aside from this joke, Sophie spent a long time studying the problem of split personality and multiple personalities, and especially subscribed to a related YouTube channel for this purpose.

Director Ginberg praised "Model Worker Sister" Jessica Chastain by name. This is the first time that Chastain has appeared in a superhero movie. She has many ideas of her own, and even the voice of the role has to be carefully designed. As the villain in the film, she chose an unusually cold voice for her role, just like the plain and calm voice of a veterinarian when he gave a notice of "humane destruction" to a pet owner.

Alita crew

Mutant team launches cosmic rescue film showing more role conflicts.

"X-Men: Dark Phoenix" broadcast a 13-minute movie clip on the spot, focusing on a special action of the X-Men squad. A spaceship encountered a strange event in the universe. After receiving a call from the President for help, Professor X decided to send a team to rescue the universe. Although many players have doubts about this, in the end, Raven led Jean Grey, Laser Eye, Fast Silver, Storm and Nightcrawler on the X-Jet. Under the command of Raven, the team members cooperated with each other to rescue the crew of the spaceship, and only the commander of the spaceship remained on the spaceship. At this time, the spacecraft is about to disintegrate, and the cosmic energy is about to devour everything, but Professor X insists on rescuing the commander, and also specifically asks Jean Grey to control the spacecraft that is about to explode. In the end, the commander was rescued, but Jean Grey was penetrated by cosmic energy rays, and all the energy rays were absorbed to protect everyone. The X-Men who returned to Earth became heroes in people’s minds, but Ruiwen fell out with Professor X, accusing him of being greedy for vanity, just to gain attention, regardless of everyone’s safety.

Director Ginberg once said that "X-Men: Dark Phoenix" is a film that highlights the internal conflicts of the X-Men, which has also been verified in the film clips. The rescue operation was opposed by Hank (Beast), and Jean Grey also communicated with Raven privately. Without reading minds, she can feel that Raven is as worried as she is. After the action, Raven had an argument with the professor. She accused the professor of being greedy for vanity and putting the team members in danger, and even ridiculed that the latter would not "get involved in danger" and "save the world by women". "X-Men should be renamed X-WOMEN". The only 13-minute fragment has fully revealed the division within the team, and also laid the groundwork for the blackening of the piano and the civil war of the team. "X-Men: Dark Phoenix" will land in the North American film market on June 7, 2019.

The props help the amazing special effects "Alita: Fighting Angel" to share the long clips.

Alita: Fighting Angel is a blockbuster science fiction masterpiece, which will land in North America on February 14th, 2019. This time, FOSS played a 22-minute film clip at the comic exhibition, covering several important time nodes in the film, centering on the protagonist Alita, from her awakening, stepping into the scrap metal city, getting to know Hugo, to her awakening the warrior instinct and launching a fierce battle with the enemy. Director Robert Rodriguez, producer Jon Landau, two leading actors Rosa Salazar and Keean Keean Johnson shared the behind-the-scenes tidbits of Alita: Fighting Angel with fans. Producer Landau is the creative partner of great director James Cameron for many years, and he has also published some little-known behind-the-scenes stories. The project "Contact between Ka Shen and Landau" was in 1999, and it was learned through another "otaku" director, Guillermo Del Toro. Card god wanted to write and direct at first, but it was not until 2005 that he wrote his own satisfactory script. As a result, Ka Shen was busy with Avatar at that time, so he had to give up the project and chose Rodriguez as the director. He didn’t direct it himself, but Ka Shen still had high hopes for this film. According to Landau, Ka Shen was originally going to practice filming Avatar first.I will use skilled technology in Alita: Fighting Angel. I didn’t expect that the technology used in Alita: Fighting Angel will benefit the sequel of Avatar a lot.

Rosa Sa lazare began five months of physical training the day after she got the role. She spends several hours every day receiving training in Muay Thai and boxing, which she thinks is not only a physical training, but also a mental and spiritual training. When filming, she also has to stand upright and imitate the standing posture of robots, which is also a big challenge for her. The amazing pictures and special effects of this film are inseparable from CGI, but the crew also created a lot of real scenes and props. Many scenes in the film are real, and there are a lot of real props and extras. Johnson, who plays Hugo, revealed: "The scene during the live shooting is really like a lively city. There are more than 200 sets of costumes in the wardrobe of the crew, and there are many mechanical arm props that look very realistic. The flying motorcycle I rode in the movie is also real, but I can’t fly. "

Murder at the Royal Hotel: Word-of-mouth explosion Black comedy pays tribute to the crazy 1960s.

The highly anticipated thriller "Murder of the Royal Hotel" has appeared in several film festivals before, and the media reputation is quite good. This time, FOSS also held a film-watching event in NYCC, and the response after the screening was also good. The film took place in a poorly run hotel near Lake Tahoe, where a group of strangers with different intentions met by chance and settled in at the same time. What happened afterwards was unexpected, and the dark background of the hotel itself was gradually revealed. The Wrap praised this film as a rare and vibrant work in the film industry today. Some people may use "indulgence" to describe the film style, but "decadence" may be a more appropriate adjective. Culturess thinks this film is a hilarious black comedy, paying tribute to the paranoid and crazy 1960s. IndieWire commented that the more director Gundam reversed the fans’ guesses and perceptions of the good and evil characters in the film, the more people deeply understood and supported these characters to return to the right path and integrate into society. The film has a lot of preaching elements, but it is carried out in a way that encourages everyone and makes them feel the feelings of these characters.

Murder at the Royal Hotel is a new work by Drew Goddard, a genius director. The suspense elements, closed scenes and dark style of the film are quite similar to hateful eight directed by Quentin Tarantino. Jeff Bridges, Dakota Johnson, Jon Hamm, and Cynthia Erivo gave wonderful performances, and the evil cult leader played by "Hammer Brother" Chris Hemsworth was even more amazing. The murder of the Royal Hotel will be fully released in North America on October 12th.

　　CCTV News:On the morning of April 26th, the 14th China International Cartoon & Animation Festival Animation Film Promotion and Venture Capital Fair officially kicked off in Yichuang Town, Xihu District, Hangzhou. During the two-day event, 26 upcoming heavy animation films and venture capital projects, such as Adventure in Mysterious World 4, Adventure in the Deep Sea, Submarine Story: Two Wan Li under the Sea, The Boxer Empire, Life and Death Bull Ring, Two Pretty princesses, Growing Up Every Day, The Adventure of the Puppy, The Legend of the Elephant, took turns to stage to promote roadshows, attracting important national cinema lines. And nearly 200 guests from China Film Co., Wanda, Alibaba Pictures, Iqiyi, Huaqiang and other important production and publicity companies watched, exchanged and discussed cooperation on the spot, which promoted the great development of China animation film industry.

　　This year’s Animation Film Promotion and Venture Capital Fair was hosted by China International Cartoon & Animation Festival Executive Committee, undertaken by Xihu District Committee of the Communist Party of China, Xihu District People’s Government and China International Animation Festival Exhibition Office, and co-organized by Juyinghui (Beijing) Film and Television Culture Co., Ltd., Yichuang Town and Hangzhou China International Cartoon & Animation Festival Exhibition Co., Ltd. as executing units. Zhang Genming, Party Secretary of Xihu District, Guofu Wang, Deputy Director of Zhejiang Press, Publication, Radio, Film and Television Bureau and Deputy Director of China International Cartoon & Animation Festival Executive Committee, Wang Xiaomei, Vice Chairman of Hangzhou CPPCC and Deputy Director of China International Cartoon & Animation Festival Executive Committee, Liu Zheng, Deputy Secretary of Party Committee of China Academy of Fine Arts, and Zhang Baiqing, Honorary President of China Film Critics Association, delivered speeches and witnessed the signing ceremony of the cooperation between "Yichuang Animation Film Research and Innovation Exchange Center" and "Yichuang Phoenix Financial Plan".

　　China Animation Film Development Report (2017) was officially released.

　　On the morning of 26th, the highly anticipated China Animation Film Development Report (2017) was grandly released. The report comprehensively combs and analyzes the investment, production, content creation, marketing and promotion, distribution and screening, audience consumption and non-box office income of animated films in the past year, grasps the development pulse of the animated film industry and looks forward to the future development trend. In addition, the report also makes an in-depth analysis of vivid cases such as Journey to the Dream Ring, Daddy Thief 3, Bears in Fantasy Space, and summarizes the experience of head animation films in content creation, marketing and distribution, derivative development, etc., with a view to bringing new enlightenment to colleagues in the domestic industry through the study of "Stones from Other Mountains".

　　As the only important document dedicated to the integration of Industry-University-Research and animation in China, China Animation Film Development Report has been closely following the development trend of animation market and going deep into the practice of animation industry. Since its first publication in 2014, it has been highly praised by many industry and academic experts. This time, under the background of the increasingly obvious trend of "audience-oriented, content is king", the research on movie-watching consumption behavior and psychology of movie audiences, especially animated movie audiences, was intensified, and a nationwide survey covering nearly 10,000 people was conducted to provide the most authentic and objective first-line data for the industry personnel and guide the creation, marketing and distribution of films.

　　Zhu Yuqing, the founder of Juyinghui and editor-in-chief of China Animation Film Development Report (2017), released the data of China animation film industry in 2017 on behalf of the editorial board: in 2017, a total of 52 Chinese and foreign animation films entered the mainstream cinemas in China, with a total of 10.134 million screenings, with 143 million people watching movies and an output box office of over 4.72 billion yuan. Among them, 30 domestic animated films were released, with a total of 2.781 million screenings and 40.068 million people watching movies, achieving a box office income of 1.303 billion yuan.

　　When talking about the prospect and future development trend of the animated film market in 2018, Zhu Yuqing emphasized that in the first quarter of this year, the total number of screens in China has exceeded 54,000, and the box office has exceeded 20.2 billion yuan, up 39.8% year-on-year, returning to rapid growth, of which the animated film box office has exceeded 1.09 billion yuan. According to the latest information, this year will be a big year for animated films, and many new animated films with market potential will be released one after another, and the themes and types will be more diverse. On the one hand, parent-child family animated films, such as the sequel of a series of high-quality animated films such as Bears and Adventures in the Mysterious World, have maintained a high production level; On the other hand, more original animated films and excellent animated films focusing on "non-parent-child" people are accelerating to enter the market. All these make the overall performance of this year’s animated films highly anticipated.

　　"New era, new animation", the industry focuses on "new format" of animated films.

　　In 2017, the domestic film market returned to the fast track of development, with a cumulative box office output of 55.911 billion yuan, a year-on-year increase of 13.45%. However, in the context of the rapid development of the overall situation, what are the opportunities and challenges for animated films that are in their infancy? How will the future animated films be expanded? Where is the way for domestic original animated films? How to upgrade a series of animated films?

　　At this year’s "New Era, New Animation" animated film theme salon, Zhu Yuqing collided with senior vice president of shenzhen huaqiang Fangte Culture and Technology Group Co., Ltd., general director of "Bears Appear" series, executive deputy general manager of Huaxia Film Distribution Co., Ltd. Huang Qunfei, chairman and CEO of Zhejiang Bocai Media Co., Ltd. and other industry veterans around the above topics, and analyzed the current situation of the animated film industry and explored the development of animated films in the new era from the perspectives of its development trend, production, distribution and screening.

　　Director Ding Liang, who successfully created the series "Bears Come and Go", shared the behind-the-scenes story of this national IP creation on the spot, and pointed out that the creation of a series of animation can not be separated from the overall idea of industrial development and the precise positioning of the target population. Only by actively understanding children’s perspectives and preferences can we create works that the audience likes. In the future, the series of Bears will continue to increase investment and development in box office, derivatives and theme parks, and actively expand other new brands while extending the life cycle of the project. At the same time, Ding Liang also stressed that the future domestic animation needs to strengthen the study, collation and research in basic software technology, 3D animation mining, and the establishment of values.

　　Leo Lee, who has attracted much attention because of his two Kunta series animations, tells the story of the creation and maintenance of the animation of the start-up brand based on his own experience. He thinks that the difficulty in the creation of animated films lies in the communication of information: on the one hand, it refers to how to convey the values and world outlook contained in animated films to the audience in a quiet and simple way; On the other hand, it refers to how to make hundreds of workers convey the desired effect through a static role image at the same time. Regarding the grasping and application of the audience’s needs, Director Leo Lee thinks that as a creator, he should actually guide or even create the audience’s needs, instead of pandering blindly, and find a balance between the audience and the initial heart.

　　Huang Qunfei, who has rich experience in film distribution and investment screening management, interprets the overall changes of animated films in 2017 from a market perspective, and thinks that the decline of the animated film market in 2017 exceeding 30% and domestic animation exceeding 70% is beyond many people’s expectations, mainly due to the lack of explosions, the deep-rooted label of domestic animation and the lack of bright spots in marketing distribution. At the same time, Huang Qunfei also pointed out that 2017 is a watershed for China films, and many small literary films have achieved good results, which proves that quality films are catching the hearts of the audience. In the future, domestic animation should also seize this opportunity to make a breakthrough in family animation and build a China animation brand.

　　Zhu Yuqing, who devotes himself to film audience and market research, points out that China films have entered a "user-driven" audience era in synchronization with the current new retail era. At present, the appreciation level of movie audiences is constantly improving, which means that the creation and production of animated films must be rapidly upgraded to keep up with the audience’s cultural consumption demand, especially the story and the culture contained in it need to be carefully polished to truly win the audience’s recognition and love. "Today, when the content is king, a good film will not be buried. In the highly competitive Spring Festival this year, the box office of" Bear Infested 5 "can successfully break through 600 million yuan. Therefore, it is the top priority of animated films now and in the future to study the audience carefully and carefully create excellent films. "

　　Heavy domestic animations such as Adventure in Mysterious World 4 and Two Pretty Princesses appeared at the cinema promotion meeting.

　　At the animation film promotion meeting on 26th, Beijing Qixinran Digital Technology Co., Ltd., Shanghai Xinyue Film and Television Culture Co., Ltd., China Film Animation Industry Co., Ltd., Chuchuzhuoer Film and Television Media Co., Ltd., Jiuqian (Shanghai) Culture Communication Co., Ltd., Beijing Qingqingshu Animation Technology Co., Ltd. and other well-known animation film production and publicity companies brought "Adventure in the Mysterious World 4", "Submarine Story: Two Wan Li under the Sea", "Life and Death Bull Ring" and "Two Pretty princesses".

　　At the event site, Wang Yunfei, the general director of "Adventures in the Mysterious World" series, personally took the stage to promote "Adventures in the Mysterious World 4", interacted with the virtual animation image and the audience, and announced on the spot that the film was officially finalized on August 3, and there were even more materials specially customized for this animated film promotion and venture capital meeting. Shanghai Xinyue Film and Television Culture Co., Ltd. also brought four blockbuster films, Submarine Story: Two Wan Li under the Sea, Deep Sea Adventure, Wukong Christmas Adventure and Police Car Alliance, to make a collective appearance at one time, covering adventure, fantasy, warmth, safety education and other topics, which will be shown in the "June 1" file, summer file and Mid-Autumn Festival file respectively. With an investment of over 100 million yuan, the main scene, props and characters are as high as 72, 10,000+and 400+ respectively, and the order of magnitude is comparable to that of Zootopia’s "The Empire of Hackers". Many creative details are also announced at the promotion meeting. The film will be released in the summer next year, when more than 100 jokes, cute points and tears will come to the audience intensively.

　　The first domestic animated film "Two Pretty Princesses" with a fairy tale theme, which is also scheduled for the summer file, was created by the new army in the animation film industry — — Produced by Chuchuzhuoer Film and Television Media Co., Ltd., the film adopts 4K shooting technology and quotes the latest foreign three-dimensional animation technology, which is full of visual impact; Jilin Animation Institute, the producer of the best-selling frog kingdom series in the international market, also appeared with the latest masterpiece "The Adventure of the Fantasy Queen of the Frog Kingdom", which will be released in July. Jilin Animation Institute also announced on the spot that it will build an alumni entrepreneurial platform of "creating the world together"; The "most beautiful animated film" and "Hua Sen Ling", which successfully emerged from the Animation Festival Animation Film Venture Capital Conference, are about to be completed. This time, I returned to the event site with the latest wonderful clips. Thank you for your support and encouragement.

　　Representatives from China Film Xingmei, China Film Digital, China Film Southern Shinkansen, Zhejiang Times, Zhejiang Xingguang, Shanghai Lianhe, Poly Wanhe, Fujian Zhongxing, Liaoning North, Evergrande Cinema and other important national cinema institutions, together with representatives from Jiangsu Youman Cartoon, Hunan Golden Eagle Cartoon, Guangdong Jiajia Cartoon, Shandong Children, Jiangxi Children and Chongqing Children, made suggestions for 12 excellent films participating in roadshows.

　　New films, such as Growing Up Every Day and Indiana Jones 2, were supported by venture capital.

　　As the most professional and largest animation film venture capital meeting at present, the scene is full of surprises. After a rigorous screening of nearly 100 venture capital projects, the final "Doll Jones 2", "Growing Up Every Day", "There are beasts in this world", "Fu Xing Gao Zhao Zhu Xiaoba" and "Prince Yamaraja — Fourteen high-quality projects, such as Treading in Spring Chronicle, Dog Adventure, Legend of the Elephant, Little Child and Top Scholar, stood out and successfully entered the roadshow.

　　The cartoon "Growing Up Every Day", which was launched in 2017, once aroused the collective memories of the beautiful rural life from the 1970s to the 1990s, and was recommended as an excellent domestic animation by the State Administration of Radio, Film and Television. This time, the launch of the animated film project of the same name has attracted a lot of attention; Raiders of the Doll 2 was produced by Submarine Story series animated films — — Produced by Shenzhen Global Digital Film and Television Culture Co., Ltd., the rich experience in cultivating series of brand animations and excellent production make this film optimistic by many companies.

　　"There are beasts in this world" tells the story of the bloody adventure of the mutual crossing and interaction between the human world, the beast world and the game world under the background of the mature AR/VR technology, and at the same time reflects the inner feelings of the "floating generation" living in big cities. The film’s full creativity and exquisite painting style have won many praises; Well-made and innovative "Puppy Adventure" was jointly developed by Golden Globe screenwriter Rob Tobin and Jiangsu Golden Oak Film Industry. With the business philosophy and ideas of "China wisdom, international expression and global market", it is expected to become a new benchmark for co-animation. The 16-year-old "little broken child" will also have his own big movie — — The whole story of "Little Broken Kid’s Top Scholar" is interspersed with many traditional story segments such as Bao Qingtian, Liang Zhu, Shuihu, Journey to the West, and many popular emoticons. With a huge basic user group, profound traditional cultural heritage and easy-to-understand international image setting, "Little Broken Kid" has an extremely broad space for IP and derivatives development.

　　Many high-quality projects have attracted the participation of senior executives of major film and television investment production and production companies in China, such as Huaqiang Fantawild Animation Inc., iQiyi Film, Ali Film, Wanda Film, Lechuang Entertainment, Fujian Hengye, 1905 Film, etc., and made suggestions for animation projects participating in roadshows, and expressed strong cooperation intentions on the spot. In the end, a number of venture capital projects reached cooperation with the investment institutions present, and won the praise and blessings of the guests at the scene. "We found our favorite partner at the venture capital meeting of the animation festival. I hope that after the film is made, we can come back like" Hua Senling "to thank you!" The film representative who successfully won the favor of investment institutions told reporters.